Gene table of TBP : TATA-box binding protein

Gene-disease associations table

Disease IDDisease nameSource of annotation with TBPOMIM linkNumber of associated genesgenes
PS168600PARKINSON DISEASEClinVar, OMIM link to OMIM 30ATP13A2, FGF20, VPS13C, DNAJC13, ATXN2, PINK1, CHCHD2, ADH1C, UCHL1, GIGYF2, SYNJ1, PODXL, HTRA2, LRRK2, TBP, PARK2, ATXN8OS, SNCAIP, GBA, SNCA, NR4A2, PLA2G6, GLUD2, PARK7, ATXN3, MAPT, DNAJC6, EIF4G1, FBXO7, VPS35
PS164400SPINOCEREBELLAR ATAXIAClinVar, OMIM link to OMIM 31PRKCG, ATXN2, SCYL1, PDYN, ELOVL5, ATXN10, TRPC3, ATXN8OS, NOP56, ATXN8, TBP, PPP2R2B, ELOVL4, PLEKHG4, ATXN7, AFG3L2, BEAN1, CACNA1A, ATXN1, TTBK2, KCND3, CACNA1G, TMEM240, ATXN3, KCNC3, SPTBN2, TGM6, CCDC88C, FGF14, ITPR1, EEF2

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Annotation of the gene TBP

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Viral carcinogenesishsa052035.08
Basal transcription factorshsa030227.31
Herpes simplex infectionhsa051685.08
Epstein-Barr virus infectionhsa051694.97
Huntington's diseasehsa050165.17
HTLV-I infectionhsa051664.59
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Infectious diseaseR-HSA-56632054.47
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningR-HSA-737797.52
RNA Polymerase I Promoter EscapeR-HSA-737728.08
RNA Polymerase I Chain ElongationR-HSA-737777.18
RNA Polymerase II Promoter EscapeR-HSA-737767.52
RNA Polymerase III Transcription Initiation From Type 2 PromoterR-HSA-760668.28
RNA Polymerase I Promoter ClearanceR-HSA-738546.75
DiseaseR-HSA-16436853.33
RNA Polymerase III Transcription Initiation From Type 1 PromoterR-HSA-760618.23
Transcription of the HIV genomeR-HSA-1671726.96
Negative epigenetic regulation of rRNA expressionR-HSA-52509416.75
RNA Polymerase III Transcription InitiationR-HSA-760467.85
RNA Polymerase II Transcription Initiation And Promoter ClearanceR-HSA-760427.52
Gene ExpressionR-HSA-741602.72
HIV InfectionR-HSA-1629065.22
RNA Polymerase III Abortive And Retractive InitiationR-HSA-7494767.66
Late Phase of HIV Life CycleR-HSA-1625996.02
RNA Polymerase II Pre-transcription EventsR-HSA-6746957.01
RNA Polymerase II TranscriptionR-HSA-738576.25
SIRT1 negatively regulates rRNA ExpressionR-HSA-4273597.89
Epigenetic regulation of gene expressionR-HSA-2121656.46
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionR-HSA-5040466.16
RNA Polymerase I Transcription InitiationR-HSA-737627.43
RNA Polymerase III Transcription Initiation From Type 3 PromoterR-HSA-760718.18
RNA Polymerase I TranscriptionR-HSA-738646.72
HIV Transcription InitiationR-HSA-1671617.52
RNA Polymerase I Transcription TerminationR-HSA-738638.03
RNA Polymerase II HIV Promoter EscapeR-HSA-1671627.52
NoRC negatively regulates rRNA expressionR-HSA-4274136.81
RNA Polymerase II Transcription InitiationR-HSA-759537.52
HIV Life CycleR-HSA-1625875.89
RNA Polymerase III TranscriptionR-HSA-741587.66
Associated GO terms for Molecular function
GO termGO IDGO IC
core promoter sequence-specific DNA bindingGO:00010465.12
RNA polymerase II regulatory region DNA bindingGO:00010123.36
enzyme bindingGO:00198992.27
nucleic acid binding transcription factor activityGO:00010712.65
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
repressing transcription factor bindingGO:00704915.71
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
core promoter proximal region sequence-specific DNA bindingGO:00009873.83
double-stranded DNA bindingGO:00036903.09
transcription factor bindingGO:00081343.46
regulatory region nucleic acid bindingGO:00010673.03
core promoter proximal region DNA bindingGO:00011593.82
core promoter bindingGO:00010474.71
RNA polymerase II repressing transcription factor bindingGO:00011036.44
RNA polymerase II transcription factor bindingGO:00010855.08
transcription regulatory region DNA bindingGO:00442123.03
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009773.37
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009783.88
RNA polymerase II core promoter sequence-specific DNA bindingGO:00009795.77
bindingGO:00054880.18