Gene table of TCF7L2 : transcription factor 7 like 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TCF7L2	OMIM link	Number of associated genes	genes
125853	DIABETES MELLITUS, NONINSULIN-DEPENDENT	ClinVar, OMIM	link to OMIM	33	SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11

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Annotation of the gene TCF7L2

Associated genes in ENSEMBL

ENSG00000148737

Associated proteins - SwissProt Accession ID

Q9NQB0

Associated PDB IDs

Cytogenetic Band

10q25.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Basal cell carcinoma	hsa05217	6.79
Endometrial cancer	hsa05213	6.81
Colorectal cancer	hsa05210	6.52
Thyroid cancer	hsa05216	7.48
Pathways in cancer	hsa05200	3.98
Prostate cancer	hsa05215	6.11
Adherens junction	hsa04520	6.26
Melanogenesis	hsa04916	5.97
Acute myeloid leukemia	hsa05221	6.74
Hippo signaling pathway	hsa04390	5.37
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32
Wnt signaling pathway	hsa04310	5.49

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by Wnt	R-HSA-195721	4.79
formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.18
Diseases of signal transduction	R-HSA-5663202	4.89
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.64
Signaling by WNT in cancer	R-HSA-4791275	7.89
Peptide hormone metabolism	R-HSA-2980736	6.61
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.66
Ca2+ pathway	R-HSA-4086398	7.1
binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	10.18
Metabolism of proteins	R-HSA-392499	3.41
deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.59
TCF dependent signaling in response to WNT	R-HSA-201681	5.36
Signal Transduction	R-HSA-162582	1.78
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.46
TCF7L2 mutants don't bind CTBP	R-HSA-5339700	11.4
beta-catenin independent WNT signaling	R-HSA-3858494	5.83
Disease	R-HSA-1643685	3.33
repression of WNT target genes	R-HSA-4641265	9.28

Associated GO terms for Molecular function

GO term	GO ID	GO IC
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
core promoter proximal region DNA binding	GO:0001159	3.82
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
protein domain specific binding	GO:0019904	3.32
repressing transcription factor binding	GO:0070491	5.71
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
core promoter proximal region sequence-specific DNA binding	GO:0000987	3.83
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
double-stranded DNA binding	GO:0003690	3.09
regulatory region nucleic acid binding	GO:0001067	3.03
transcription factor binding	GO:0008134	3.46
nuclear hormone receptor binding	GO:0035257	4.7
beta-catenin binding	GO:0008013	5.3
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
enzyme binding	GO:0019899	2.27
RNA polymerase II repressing transcription factor binding	GO:0001103	6.44
hormone receptor binding	GO:0051427	4.57
receptor binding	GO:0005102	2.43
RNA polymerase II transcription factor binding	GO:0001085	5.08
transcription regulatory region DNA binding	GO:0044212	3.03
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
gamma-catenin binding	GO:0045295	7.17
armadillo repeat domain binding	GO:0070016	7.17
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GO:0000978	3.88
nucleic acid binding transcription factor activity	GO:0001071	2.65