Disease ID | Disease name | Source of annotation with TGFB1 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
219700 | CYSTIC FIBROSIS | ClinVar, OMIM | link to OMIM | 3 | TGFB1, FCGR2A, CFTR |
131300 | CAMURATI-ENGELMANN DISEASE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | TGFB1 |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Pancreatic cancer | hsa05212 | 6.56 |
Colorectal cancer | hsa05210 | 6.52 |
Renal cell carcinoma | hsa05211 | 6.6 |
Intestinal immune network for IgA production | hsa04672 | 6.79 |
Endocytosis | hsa04144 | 4.92 |
FoxO signaling pathway | hsa04068 | 5.63 |
Osteoclast differentiation | hsa04380 | 5.64 |
Hypertrophic cardiomyopathy (HCM) | hsa05410 | 6.21 |
Dilated cardiomyopathy | hsa05414 | 6.08 |
Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
Leishmaniasis | hsa05140 | 6.32 |
Amoebiasis | hsa05146 | 5.82 |
Malaria | hsa05144 | 7.15 |
Toxoplasmosis | hsa05145 | 5.71 |
HTLV-I infection | hsa05166 | 4.59 |
Hepatitis B | hsa05161 | 5.52 |
TGF-beta signaling pathway | hsa04350 | 6.41 |
Proteoglycans in cancer | hsa05205 | 5.02 |
Rheumatoid arthritis | hsa05323 | 6.05 |
Cell cycle | hsa04110 | 5.68 |
Inflammatory bowel disease (IBD) | hsa05321 | 6.43 |
Pathways in cancer | hsa05200 | 3.98 |
Hippo signaling pathway | hsa04390 | 5.37 |
Chronic myeloid leukemia | hsa05220 | 6.48 |
Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
MAPK signaling pathway | hsa04010 | 4.63 |
Tuberculosis | hsa05152 | 5.17 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 10.18 |
Platelet degranulation | R-HSA-114608 | 6.68 |
Host Interactions with Influenza Factors | R-HSA-168253 | 10.66 |
Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 6.7 |
Influenza Infection | R-HSA-168254 | 5.86 |
Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 10.18 |
Extracellular matrix organization | R-HSA-1474244 | 4.91 |
Molecules associated with elastic fibres | R-HSA-2129379 | 7.73 |
Developmental Biology | R-HSA-1266738 | 3.48 |
TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 10.98 |
Elastic fibre formation | R-HSA-1566948 | 7.49 |
Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
ECM proteoglycans | R-HSA-3000178 | 6.75 |
TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 10.18 |
TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 10.98 |
Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 10.18 |
Syndecan interactions | R-HSA-3000170 | 8.23 |
Non-integrin membrane-ECM interactions | R-HSA-3000171 | 7.1 |
Infectious disease | R-HSA-5663205 | 4.47 |
SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 10.4 |
Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 9.98 |
Diseases of signal transduction | R-HSA-5663202 | 4.89 |
Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 6.81 |
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 8.98 |
Disease | R-HSA-1643685 | 3.33 |
TGFBR2 MSI Frameshift Mutants in Cancer | R-HSA-3642279 | 11.98 |
Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 10.98 |
Influenza Virus Induced Apoptosis | R-HSA-168277 | 11.98 |
TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 7.98 |
Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 8.28 |
Hemostasis | R-HSA-109582 | 3.98 |
Signal Transduction | R-HSA-162582 | 1.78 |
GO term | GO ID | GO IC |
---|---|---|
cytokine receptor binding | GO:0005126 | 4.14 |
cytokine activity | GO:0005125 | 4.34 |
antigen binding | GO:0003823 | 5.02 |
transforming growth factor beta receptor binding | GO:0005160 | 5.81 |
kinase activator activity | GO:0019209 | 5.58 |
enzyme binding | GO:0019899 | 2.27 |
binding | GO:0005488 | 0.18 |
molecular function regulator | GO:0098772 | 2.51 |
kinase regulator activity | GO:0019207 | 4.5 |
glycoprotein binding | GO:0001948 | 5.11 |
growth factor activity | GO:0008083 | 4.66 |
protein dimerization activity | GO:0046983 | 2.72 |
type II transforming growth factor beta receptor binding | GO:0005114 | 7.79 |
identical protein binding | GO:0042802 | 2.63 |
protein homodimerization activity | GO:0042803 | 3.16 |
protein kinase regulator activity | GO:0019887 | 4.6 |
enzyme regulator activity | GO:0030234 | 2.85 |
type III transforming growth factor beta receptor binding | GO:0034714 | 8.35 |
type I transforming growth factor beta receptor binding | GO:0034713 | 7.44 |
protein kinase activator activity | GO:0030295 | 5.68 |
protein serine/threonine kinase activator activity | GO:0043539 | 6.91 |
protein N-terminus binding | GO:0047485 | 5.11 |
carbohydrate derivative binding | GO:0097367 | 2.03 |
protein binding | GO:0005515 | 0.46 |
receptor binding | GO:0005102 | 2.43 |
protein heterodimerization activity | GO:0046982 | 3.64 |
enzyme activator activity | GO:0008047 | 3.56 |