Gene table of TGIF1 : TGFB induced factor homeobox 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with TGIF1OMIM linkNumber of associated genesgenes
PS236100HOLOPROSENCEPHALYClinVar, OMIM, HUMSAVAR link to OMIM 8GAS1, PTCH1, GLI2, SIX3, SHH, TGIF1, CDON, ZIC2

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Annotation of the gene TGIF1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Generic Transcription PathwayR-HSA-2124363.86
Gene ExpressionR-HSA-741602.72
Signaling by TGF-beta Receptor ComplexR-HSA-1708346.81
Signal TransductionR-HSA-1625821.78
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerR-HSA-21737937.56
Downregulation of SMAD2/3:SMAD4 transcriptional activityR-HSA-21737958.46
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-21737968.03
Associated GO terms for Molecular function
GO termGO IDGO IC
RNA polymerase II regulatory region DNA bindingGO:00010123.36
core promoter proximal region DNA bindingGO:00011593.82
nucleic acid binding transcription factor activityGO:00010712.65
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010785.08
heterocyclic compound bindingGO:19013631.06
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
transcription corepressor activityGO:00037144.33
transcription cofactor activityGO:00037123.44
co-SMAD bindingGO:00704107.25
transcription factor activity, protein bindingGO:00009883.35
core promoter proximal region sequence-specific DNA bindingGO:00009873.83
double-stranded DNA bindingGO:00036903.09
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00009823.94
RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:00009813.29
transcription factor activity, transcription factor bindingGO:00009893.36
regulatory region nucleic acid bindingGO:00010673.03
SMAD bindingGO:00463325.45
transcription regulatory region DNA bindingGO:00442123.03
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012274.61
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009773.37
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009783.88
bindingGO:00054880.18