Gene table of TH : tyrosine hydroxylase

Gene-disease associations table

Disease IDDisease nameSource of annotation with THOMIM linkNumber of associated genesgenes
605407SEGAWA SYNDROME, AUTOSOMAL RECESSIVEOMIM, HUMSAVAR link to OMIM 1TH

Download the gene annotation in CSV format

Annotation of the gene TH

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Metabolic pathwayshsa011002.49
Cocaine addictionhsa050307.07
Amphetamine addictionhsa050316.62
Prolactin signaling pathwayhsa049176.6
Alcoholismhsa050345.59
Dopaminergic synapsehsa047285.69
Tyrosine metabolismhsa003507.64
Parkinson's diseasehsa050125.59
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Metabolism of amino acids and derivativesR-HSA-712915.4
Amine-derived hormonesR-HSA-2097768.98
Catecholamine biosynthesisR-HSA-20990510.98
MetabolismR-HSA-14307282.34
Associated GO terms for Molecular function
GO termGO IDGO IC
monooxygenase activityGO:00044975.1
enzyme bindingGO:00198992.27
dopamine bindingGO:00352407.34
bindingGO:00054880.18
amino acid bindingGO:00165975.71
heterocyclic compound bindingGO:19013631.06
oxidoreductase activityGO:00164913.12
anion bindingGO:00431684.17
coenzyme bindingGO:00506624.53
transition metal ion bindingGO:00469142.48
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:00167054.65
ion bindingGO:00431671.36
iron ion bindingGO:00055064.65
metal ion bindingGO:00468721.41
cation bindingGO:00431691.4
tetrahydrobiopterin bindingGO:00346178.35
ferrous iron bindingGO:00081986.65
catalytic activityGO:00038241.05
cofactor bindingGO:00480374.16
protein domain specific bindingGO:00199043.32
tyrosine 3-monooxygenase activityGO:00045119.74
oxygen bindingGO:00198255.89
ferric iron bindingGO:00081997.44
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygenGO:00167147.79
carboxylic acid bindingGO:00314064.64
protein bindingGO:00055150.46
catecholamine bindingGO:19013386.97
organic cyclic compound bindingGO:00971591.05