Gene table of THRA : thyroid hormone receptor, alpha

Gene-disease associations table

Disease ID	Disease name	Source of annotation with THRA	OMIM link	Number of associated genes	genes
PS275200	HYPOTHYROIDISM, CONGENITAL, NONGOITROUS	ClinVar, OMIM, HUMSAVAR	link to OMIM	5	PAX8, THRA, NKX2-5, TSHB, TSHR

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Annotation of the gene THRA

Associated genes in ENSEMBL

ENSG00000126351

Associated proteins - SwissProt Accession ID

P10827

Associated PDB IDs

Cytogenetic Band

17q21.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Thyroid hormone signaling pathway	hsa04919	5.82
Neuroactive ligand-receptor interaction	hsa04080	4.58

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Nuclear Receptor transcription pathway	R-HSA-383280	7.31
Generic Transcription Pathway	R-HSA-212436	3.86
Gene Expression	R-HSA-74160	2.72

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
nucleic acid binding	GO:0003676	1.44
TBP-class protein binding	GO:0017025	6.74
chromatin DNA binding	GO:0031490	5.37
transcription factor activity, direct ligand regulated sequence-specific DNA binding	GO:0098531	5.87
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	GO:0004879	5.87
hormone binding	GO:0042562	5.53
sequence-specific DNA binding	GO:0043565	2.79
structure-specific DNA binding	GO:0043566	4.98
sequence-specific double-stranded DNA binding	GO:1990837	3.2
transition metal ion binding	GO:0046914	2.48
ion binding	GO:0043167	1.36
identical protein binding	GO:0042802	2.63
receptor activity	GO:0004872	2.32
double-stranded DNA binding	GO:0003690	3.09
metal ion binding	GO:0046872	1.41
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
protein homodimerization activity	GO:0042803	3.16
cation binding	GO:0043169	1.4
thyroid hormone binding	GO:0070324	7.95
transcription factor binding	GO:0008134	3.46
regulatory region nucleic acid binding	GO:0001067	3.03
protein complex binding	GO:0032403	3.09
protein domain specific binding	GO:0019904	3.32
steroid receptor RNA activator RNA binding	GO:0002153	9.74
intronic transcription regulatory region DNA binding	GO:0044213	7.25
transcription regulatory region DNA binding	GO:0044212	3.03
protein heterodimerization activity	GO:0046982	3.64
molecular transducer activity	GO:0060089	2.32
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
nucleic acid binding transcription factor activity	GO:0001071	2.65
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	GO:0003705	5.23
steroid hormone receptor activity	GO:0003707	5.66
single-stranded RNA binding	GO:0003727	5.5
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
protein dimerization activity	GO:0046983	2.72
chromatin binding	GO:0003682	3.64
thyroid hormone receptor activity	GO:0004887	7.66
zinc ion binding	GO:0008270	2.66