| Disease ID | Disease name | Source of annotation with TLR3 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS610551 | ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED | ClinVar, OMIM, HUMSAVAR | link to OMIM | 7 | TLR3, CPT2, IRF3, TICAM1, UNC93B1, TRAF3, RANBP2 |
| 609423 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO | ClinVar, OMIM | link to OMIM | 16 | HLA-C, IFNG, CCL3, CD209, IL4R, KIR3DL1, CCL2, TLR3, CCR2, CX3CR1, CCL11, CCR5, CXCL12, CCL3L1, CXCR1, IL10 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Influenza A | hsa05164 | 5.21 |
| Hepatitis C | hsa05160 | 5.68 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| Hepatitis B | hsa05161 | 5.52 |
| Herpes simplex infection | hsa05168 | 5.08 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 8.46 |
| Immune System | R-HSA-168256 | 2.37 |
| TICAM1 deficiency - HSE | R-HSA-5602566 | 11.98 |
| Ligand-dependent caspase activation | R-HSA-140534 | 9.08 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Disease | R-HSA-1643685 | 3.33 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 8.28 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| Caspase activation via extrinsic apoptotic signalig pathway | R-HSA-5357769 | 8.34 |
| TRAF6 mediated induction of TAK1 complex | R-HSA-937072 | 8.98 |
| TLR3 deficiency - HSE | R-HSA-5602410 | 12.98 |
| TRAF3 deficiency - HSE | R-HSA-5602571 | 11.4 |
| UNC93B1 deficiency - HSE | R-HSA-5602415 | 11.98 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 9.28 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 9.66 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 8.59 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 6.94 |
| Diseases of Immune System | R-HSA-5260271 | 8.34 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.34 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Apoptosis | R-HSA-109581 | 5.68 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | R-HSA-936964 | 8.81 |
| GO term | GO ID | GO IC |
|---|---|---|
| identical protein binding | GO:0042802 | 2.63 |
| signaling receptor activity | GO:0038023 | 2.49 |
| nucleic acid binding | GO:0003676 | 1.44 |
| protein binding | GO:0005515 | 0.46 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| double-stranded RNA binding | GO:0003725 | 5.58 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| receptor activity | GO:0004872 | 2.32 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| RNA binding | GO:0003723 | 2.36 |