| Disease ID | Disease name | Source of annotation with TLR4 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS603075 | MACULAR DEGENERATION, AGE-RELATED | OMIM | link to OMIM | 19 | RAX2, HMCN1, ERCC6, TLR4, CFHR3, CFI, CFHR1, CFH, C3, HTRA1, ABCA4, CX3CR1, FBLN5, C2, CFB, CST3, APOE, ARMS2, C9 |
| 114500 | COLORECTAL CANCER | OMIM | link to OMIM | 30 | TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pertussis | hsa05133 | 6.46 |
| Salmonella infection | hsa05132 | 6.29 |
| Pathogenic Escherichia coli infection | hsa05130 | 6.99 |
| Legionellosis | hsa05134 | 6.88 |
| Proteoglycans in cancer | hsa05205 | 5.02 |
| Rheumatoid arthritis | hsa05323 | 6.05 |
| Inflammatory bowel disease (IBD) | hsa05321 | 6.43 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| Tuberculosis | hsa05152 | 5.17 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| HIF-1 signaling pathway | hsa04066 | 5.9 |
| Leishmaniasis | hsa05140 | 6.32 |
| Amoebiasis | hsa05146 | 5.82 |
| Malaria | hsa05144 | 7.15 |
| Toxoplasmosis | hsa05145 | 5.71 |
| Influenza A | hsa05164 | 5.21 |
| Phagosome | hsa04145 | 5.27 |
| NF-kappa B signaling pathway | hsa04064 | 6.21 |
| Hepatitis B | hsa05161 | 5.52 |
| Measles | hsa05162 | 5.6 |
| PI3K-Akt signaling pathway | hsa04151 | 4.21 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 8.46 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 6.51 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| Ligand-dependent caspase activation | R-HSA-140534 | 9.08 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 9.52 |
| Disease | R-HSA-1643685 | 3.33 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 6.56 |
| TRAF6 mediated induction of TAK1 complex | R-HSA-937072 | 8.98 |
| Immune System | R-HSA-168256 | 2.37 |
| Caspase activation via extrinsic apoptotic signalig pathway | R-HSA-5357769 | 8.34 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 9.66 |
| Diseases of Immune System | R-HSA-5260271 | 8.34 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 6.51 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 9.52 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.34 |
| MyD88:Mal cascade initiated on plasma membrane | R-HSA-166058 | 6.56 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Apoptosis | R-HSA-109581 | 5.68 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | R-HSA-936964 | 8.81 |
| GO term | GO ID | GO IC |
|---|---|---|
| signaling receptor activity | GO:0038023 | 2.49 |
| protein binding | GO:0005515 | 0.46 |
| signaling pattern recognition receptor activity | GO:0008329 | 6.91 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| pattern recognition receptor activity | GO:0038187 | 6.91 |
| lipid binding | GO:0008289 | 3.26 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| lipopolysaccharide receptor activity | GO:0001875 | 8.13 |
| lipopolysaccharide binding | GO:0001530 | 6.69 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| receptor activity | GO:0004872 | 2.32 |