Gene table of TP63 : tumor protein p63

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TP63	OMIM link	Number of associated genes	genes
603543	LIMB-MAMMARY SYNDROME	OMIM	link to OMIM	1	TP63
106260	ANKYLOBLEPHARON-ECTODERMAL DEFECTS-CLEFT LIP/PALATE	OMIM, HUMSAVAR	link to OMIM	1	TP63
PS119530	OROFACIAL CLEFT	ClinVar, OMIM, HUMSAVAR	link to OMIM	6	TP63, BMP4, IRF6, MSX1, NECTIN1, SUMO1
103285	ADULT SYNDROME	OMIM, HUMSAVAR	link to OMIM	1	TP63
604292	ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	TP63
PS183600	SPLIT-HAND/FOOT MALFORMATION	ClinVar, OMIM, HUMSAVAR	link to OMIM	4	TP63, ZAK, WNT10B, DLX5

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Annotation of the gene TP63

Associated genes in ENSEMBL

ENSG00000073282

Associated proteins - SwissProt Accession ID

Q9H3D4

Associated PDB IDs

Cytogenetic Band

3q28

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
MicroRNAs in cancer	hsa05206	5.38

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Generic Transcription Pathway	R-HSA-212436	3.86
Transcriptional Regulation by TP53	R-HSA-3700989	6.73
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73
Gene Expression	R-HSA-74160	2.72

Associated GO terms for Molecular function

GO term	GO ID	GO IC
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001077	4.31
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
WW domain binding	GO:0050699	6.34
ion binding	GO:0043167	1.36
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
double-stranded DNA binding	GO:0003690	3.09
metal ion binding	GO:0046872	1.41
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
cation binding	GO:0043169	1.4
regulatory region nucleic acid binding	GO:0001067	3.03
protein domain specific binding	GO:0019904	3.32
transcription regulatory region DNA binding	GO:0044212	3.03
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
chromatin binding	GO:0003682	3.64
p53 binding	GO:0002039	5.53
damaged DNA binding	GO:0003684	5.58
nucleic acid binding transcription factor activity	GO:0001071	2.65