Gene table of TRAF3 : TNF receptor associated factor 3

Gene-disease associations table

Disease IDDisease nameSource of annotation with TRAF3OMIM linkNumber of associated genesgenes
PS610551ENCEPHALOPATHY, ACUTE, INFECTION-INDUCEDClinVar, OMIM, HUMSAVAR link to OMIM 7TLR3, CPT2, IRF3, TICAM1, UNC93B1, TRAF3, RANBP2

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Annotation of the gene TRAF3

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Viral carcinogenesishsa052035.08
Toll-like receptor signaling pathwayhsa046206.0
Pathways in cancerhsa052003.98
RIG-I-like receptor signaling pathwayhsa046226.62
Herpes simplex infectionhsa051685.08
Epstein-Barr virus infectionhsa051694.97
TNF signaling pathwayhsa046685.96
NF-kappa B signaling pathwayhsa040646.21
Hepatitis Chsa051605.68
Small cell lung cancerhsa052226.17
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Cytokine Signaling in Immune systemR-HSA-12802153.74
TNFR2 non-canonical NF-kB pathwayR-HSA-56685416.4
TRAF3-dependent IRF activation pathwayR-HSA-9182339.18
Innate Immune SystemR-HSA-1682493.17
TRAF3 deficiency - HSER-HSA-560257111.4
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Toll-Like Receptors CascadesR-HSA-1688985.91
Diseases of Immune SystemR-HSA-52602718.34
Diseases associated with the TLR signaling cascadeR-HSA-56023588.34
Immune SystemR-HSA-1682562.37
Negative regulators of RIG-I/MDA5 signalingR-HSA-9364407.98
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayR-HSA-56765948.89
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
Activated TLR4 signallingR-HSA-1660546.27
DiseaseR-HSA-16436853.33
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonR-HSA-9369648.81
Associated GO terms for Molecular function
GO termGO IDGO IC
cytokine receptor bindingGO:00051264.14
ubiquitin-like protein ligase bindingGO:00443894.15
enzyme bindingGO:00198992.27
bindingGO:00054880.18
signal transducer activityGO:00048712.28
ubiquitin-like protein transferase activityGO:00197873.69
cation bindingGO:00431691.4
transition metal ion bindingGO:00469142.48
ligase activityGO:00168743.72
ion bindingGO:00431671.36
transferase activityGO:00167401.95
metal ion bindingGO:00468721.41
tumor necrosis factor receptor superfamily bindingGO:00328135.89
protein kinase bindingGO:00199013.44
catalytic activityGO:00038241.05
protein phosphatase bindingGO:00199034.93
phosphatase bindingGO:00199024.63
tumor necrosis factor receptor bindingGO:00051646.3
ubiquitin-protein transferase activityGO:00048423.73
ubiquitin protein ligase bindingGO:00316254.17
thioesterase bindingGO:00319967.25
kinase bindingGO:00199003.32
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
zinc ion bindingGO:00082702.66