Gene table of TYK2 : tyrosine kinase 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TYK2	OMIM link	Number of associated genes	genes
611521	IMMUNODEFICIENCY 35	ClinVar, OMIM	link to OMIM	1	TYK2

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Osteoclast differentiation	hsa04380	5.64
Jak-STAT signaling pathway	hsa04630	5.44
Herpes simplex infection	hsa05168	5.08
Epstein-Barr virus infection	hsa05169	4.97
Toxoplasmosis	hsa05145	5.71
Influenza A	hsa05164	5.21
Hepatitis C	hsa05160	5.68
Measles	hsa05162	5.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Interleukin-6 signaling	R-HSA-1059683	9.52
MAPK family signaling cascades	R-HSA-5683057	4.89
Signaling by Interleukins	R-HSA-449147	4.71
Immune System	R-HSA-168256	2.37
MAPK1 (ERK2) activation	R-HSA-112411	9.81
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Regulation of IFNA signaling	R-HSA-912694	8.34
Interferon alpha/beta signaling	R-HSA-909733	6.04
Interferon Signaling	R-HSA-913531	4.95
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11
MAPK3 (ERK1) activation	R-HSA-110056	9.66
Signal Transduction	R-HSA-162582	1.78
RAF-independent MAPK1/3 activation	R-HSA-112409	8.46

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
G-protein coupled receptor binding	GO:0001664	4.18
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
ribonucleoside binding	GO:0032549	2.22
nucleotide binding	GO:0000166	1.96
transferase activity	GO:0016740	1.95
non-membrane spanning protein tyrosine kinase activity	GO:0004715	5.91
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
growth hormone receptor binding	GO:0005131	8.13
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
angiotensin receptor binding	GO:0031701	7.25
catalytic activity	GO:0003824	1.05
type 1 angiotensin receptor binding	GO:0031702	7.44
hormone receptor binding	GO:0051427	4.57
small molecule binding	GO:0036094	1.89
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19