Disease ID | Disease name | Source of annotation with UGT1A4 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS237450 | HYPERBILIRUBINEMIA | ClinVar, HUMSAVAR | link to OMIM | 5 | UGT1A1, SLCO1B1, ABCC2, SLCO1B3, UGT1A4 |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Metabolism of xenobiotics by cytochrome P450 | hsa00980 | 6.48 |
Porphyrin and chlorophyll metabolism | hsa00860 | 7.41 |
Drug metabolism - cytochrome P450 | hsa00982 | 6.6 |
Retinol metabolism | hsa00830 | 6.79 |
Drug metabolism - other enzymes | hsa00983 | 7.21 |
Steroid hormone biosynthesis | hsa00140 | 6.93 |
Ascorbate and aldarate metabolism | hsa00053 | 8.07 |
Starch and sucrose metabolism | hsa00500 | 6.91 |
Chemical carcinogenesis | hsa05204 | 6.36 |
Pentose and glucuronate interconversions | hsa00040 | 7.68 |
Metabolic pathways | hsa01100 | 2.49 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Glucuronidation | R-HSA-156588 | 8.73 |
Biological oxidations | R-HSA-211859 | 5.55 |
Phase II conjugation | R-HSA-156580 | 6.52 |
Diseases of metabolism | R-HSA-5668914 | 6.57 |
Metabolism | R-HSA-1430728 | 2.34 |
Metabolic disorders of biological oxidation enzymes | R-HSA-5579029 | 7.85 |
Metabolism of porphyrins | R-HSA-189445 | 8.89 |
Defective UGT1A4 causes hyperbilirubinemia | R-HSA-5579016 | 12.98 |
Heme degradation | R-HSA-189483 | 10.4 |
Disease | R-HSA-1643685 | 3.33 |
GO term | GO ID | GO IC |
---|---|---|
anion binding | GO:0043168 | 4.17 |
retinoid binding | GO:0005501 | 6.1 |
protein heterodimerization activity | GO:0046982 | 3.64 |
transferase activity, transferring glycosyl groups | GO:0016757 | 4.08 |
carboxylic acid binding | GO:0031406 | 4.64 |
isoprenoid binding | GO:0019840 | 6.05 |
lipid binding | GO:0008289 | 3.26 |
enzyme binding | GO:0019899 | 2.27 |
ion binding | GO:0043167 | 1.36 |
catalytic activity | GO:0003824 | 1.05 |
transferase activity | GO:0016740 | 1.95 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |
retinoic acid binding | GO:0001972 | 6.6 |
transferase activity, transferring hexosyl groups | GO:0016758 | 4.43 |
protein dimerization activity | GO:0046983 | 2.72 |
protein homodimerization activity | GO:0042803 | 3.16 |
UDP-glycosyltransferase activity | GO:0008194 | 4.81 |
monocarboxylic acid binding | GO:0033293 | 5.61 |
identical protein binding | GO:0042802 | 2.63 |
glucuronosyltransferase activity | GO:0015020 | 6.27 |