Gene table of XBP1 : X-box binding protein 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with XBP1	OMIM link	Number of associated genes	genes
612371	MAJOR AFFECTIVE DISORDER 7	OMIM	link to OMIM	1	XBP1

Download the gene annotation in CSV format

Annotation of the gene XBP1

Associated genes in ENSEMBL

ENSG00000100219

Associated proteins - SwissProt Accession ID

P17861

Associated PDB IDs

Cytogenetic Band

22q12.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Protein processing in endoplasmic reticulum	hsa04141	5.35
HTLV-I infection	hsa05166	4.59
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Unfolded Protein Response (UPR)	R-HSA-381119	6.56
ATF6-alpha activates chaperones	R-HSA-381033	9.4
XBP1(S) activates chaperone genes	R-HSA-381038	7.25
ATF6-alpha activates chaperone genes	R-HSA-381183	9.66
Metabolism of proteins	R-HSA-392499	3.41
IRE1alpha activates chaperones	R-HSA-381070	7.2

Associated GO terms for Molecular function

GO term	GO ID	GO IC
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
ubiquitin-like protein ligase binding	GO:0044389	4.15
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
enzyme binding	GO:0019899	2.27
enhancer sequence-specific DNA binding	GO:0001158	5.36
chromatin DNA binding	GO:0031490	5.37
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
structure-specific DNA binding	GO:0043566	4.98
sequence-specific double-stranded DNA binding	GO:1990837	3.2
phosphatidylinositol 3-kinase binding	GO:0043548	6.41
phosphatidylinositol 3-kinase regulatory subunit binding	GO:0036312	7.44
protease binding	GO:0002020	5.08
double-stranded DNA binding	GO:0003690	3.09
histone deacetylase binding	GO:0042826	5.08
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
steroid hormone receptor binding	GO:0035258	5.32
estrogen receptor binding	GO:0030331	6.05
regulatory region nucleic acid binding	GO:0001067	3.03
transcription factor binding	GO:0008134	3.46
nuclear hormone receptor binding	GO:0035257	4.7
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
ubiquitin protein ligase binding	GO:0031625	4.17
enhancer binding	GO:0035326	5.21
core promoter binding	GO:0001047	4.71
hormone receptor binding	GO:0051427	4.57
receptor binding	GO:0005102	2.43
RNA polymerase II transcription factor binding	GO:0001085	5.08
transcription regulatory region DNA binding	GO:0044212	3.03
chromatin binding	GO:0003682	3.64
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
protein dimerization activity	GO:0046983	2.72
protein heterodimerization activity	GO:0046982	3.64
nucleic acid binding transcription factor activity	GO:0001071	2.65