| Disease ID | Disease name | Source of annotation with XIAP | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS308240 | LYMPHOPROLIFERATIVE SYNDROME | ClinVar, OMIM | link to OMIM | 4 | ITK, SH2D1A, CD27, XIAP |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Ubiquitin mediated proteolysis | hsa04120 | 5.63 |
| Pathways in cancer | hsa05200 | 3.98 |
| Small cell lung cancer | hsa05222 | 6.17 |
| Focal adhesion | hsa04510 | 4.92 |
| Toxoplasmosis | hsa05145 | 5.71 |
| Apoptosis | hsa04210 | 6.23 |
| NF-kappa B signaling pathway | hsa04064 | 6.21 |
| HTLV-I infection | hsa05166 | 4.59 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| SMAC-mediated apoptotic response | R-HSA-111469 | 10.66 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 8.98 |
| SMAC-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 10.66 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 8.81 |
| SMAC binds to IAPs | R-HSA-111463 | 10.66 |
| Regulated Necrosis | R-HSA-5218859 | 8.81 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| Apoptotic factor-mediated response | R-HSA-111471 | 10.18 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 7.59 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 7.73 |
| Apoptosis | R-HSA-109581 | 5.68 |
| GO term | GO ID | GO IC |
|---|---|---|
| peptidase inhibitor activity | GO:0030414 | 4.55 |
| binding | GO:0005488 | 0.18 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| molecular function regulator | GO:0098772 | 2.51 |
| ubiquitin-like protein transferase activity | GO:0019787 | 3.69 |
| cation binding | GO:0043169 | 1.4 |
| transition metal ion binding | GO:0046914 | 2.48 |
| ubiquitin protein ligase activity | GO:0061630 | 4.47 |
| ion binding | GO:0043167 | 1.36 |
| cysteine-type endopeptidase regulator activity involved in apoptotic process | GO:0043028 | 6.02 |
| transferase activity | GO:0016740 | 1.95 |
| metal ion binding | GO:0046872 | 1.41 |
| endopeptidase regulator activity | GO:0061135 | 4.57 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | GO:0043027 | 6.6 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| peptidase regulator activity | GO:0061134 | 4.37 |
| catalytic activity | GO:0003824 | 1.05 |
| endopeptidase inhibitor activity | GO:0004866 | 4.6 |
| cysteine-type endopeptidase inhibitor activity | GO:0004869 | 5.71 |
| ubiquitin-protein transferase activity | GO:0004842 | 3.73 |
| ubiquitin-like protein ligase activity | GO:0061659 | 4.44 |
| protein binding | GO:0005515 | 0.46 |
| ligase activity | GO:0016874 | 3.72 |
| zinc ion binding | GO:0008270 | 2.66 |