Gene table of YARS : tyrosyl-tRNA synthetase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with YARS	OMIM link	Number of associated genes	genes
PS118220	CHARCOT-MARIE-TOOTH DISEASE	ClinVar, OMIM, HUMSAVAR	link to OMIM	48	KARS, FIG4, PRPS1, FGD4, MPZ, KIF1B, RAB7A, LMNA, VCP, GDAP1, AIFM1, MORC2, SH3TC2, TRIM2, JPH1, PLEKHG5, DNM2, NAGLU, MTMR2, HARS, HSPB8, HSPB1, PMP22, MED25, SPG11, SBF1, DYNC1H1, SURF1, NEFH, NDRG1, MARS, SBF2, IGHMBP2, NEFL, EGR2, AARS, COX6A1, PDK3, DHTKD1, HK1, GJB1, LRSAM1, PRX, TRPV4, LITAF, MFN2, YARS, GARS

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Aminoacyl-tRNA biosynthesis	hsa00970	7.31

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Cytosolic tRNA aminoacylation	R-HSA-379716	8.4
tRNA Aminoacylation	R-HSA-379724	7.59
Gene Expression	R-HSA-74160	2.72

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
signal transducer activity	GO:0004871	2.28
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
G-protein coupled receptor binding	GO:0001664	4.18
valine-tRNA ligase activity	GO:0004832	8.64
tyrosine-tRNA ligase activity	GO:0004831	9.05
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
aminoacyl-tRNA ligase activity	GO:0004812	5.93
nucleotide binding	GO:0000166	1.96
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
interleukin-8 receptor binding	GO:0005153	9.05
chemokine receptor binding	GO:0042379	5.7
poly(A) RNA binding	GO:0044822	2.69
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
tRNA binding	GO:0000049	5.95
CXCR chemokine receptor binding	GO:0045236	6.97
ligase activity	GO:0016874	3.72
ligase activity, forming carbon-oxygen bonds	GO:0016875	5.93
ligase activity, forming aminoacyl-tRNA and related compounds	GO:0016876	5.93
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
adenyl ribonucleotide binding	GO:0032559	2.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19