Gene table of ZAP70 : zeta chain of T cell receptor associated protein kinase 70

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ZAP70	OMIM link	Number of associated genes	genes
269840	IMMUNODEFICIENCY 48	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	ZAP70

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
T cell receptor signaling pathway	hsa04660	6.01
Natural killer cell mediated cytotoxicity	hsa04650	5.53
NF-kappa B signaling pathway	hsa04064	6.21
Ras signaling pathway	hsa04014	4.9
Primary immunodeficiency	hsa05340	7.52

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Generation of second messenger molecules	R-HSA-202433	7.34
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	7.81
Immune System	R-HSA-168256	2.37
Adaptive Immune System	R-HSA-1280218	3.19
TCR signaling	R-HSA-202403	6.64

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
protein phosphorylated amino acid binding	GO:0045309	6.56
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
nucleotide binding	GO:0000166	1.96
transferase activity	GO:0016740	1.95
non-membrane spanning protein tyrosine kinase activity	GO:0004715	5.91
protein tyrosine kinase activity	GO:0004713	4.54
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
phosphotyrosine binding	GO:0001784	7.03
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphoprotein binding	GO:0051219	5.64
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
ATP binding	GO:0005524	2.43
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19