Gene | Associated with PERSISTENT MULLERIAN DUCT SYNDROME, TYPES I AND II in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
AMH | OMIM, HUMSAVAR | HGNC link | 19p13.3 | 1 | 261550 |
AMHR2 | OMIM, HUMSAVAR | HGNC link | 12q13.13 | 1 | 261550 |
Download the disease annotation in CSV format
regulated gene | associated to this disease | # TFs | TFs | # TFs associated with this disease | TFs associated with this disease |
---|---|---|---|---|---|
AMH | YES | 10 | WT1, SF1, NR5A1, ESR1, SOX9, VDR, RELA, NR0B1, GATA4, NFKB1 | 0 | |
AMHR2 | YES | 1 | APC | 0 |
Gene1 | Gene2 | Direct Interaction | Interaction mode | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|---|
AMH | AMHR2 | Yes | activation, binding | 6 | FKBP1A, SMAD1, SMAD5, BMPR1B, SMAD9, ACVR1 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct interaction | More information |
---|---|---|---|
AMH | AMHR2 | maybe | They interact as ligand and receptor. |
KEGG term | KEGG term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
TGF-beta signaling pathway | hsa04350 | 6.41 | 2 | AMH, AMHR2 |
Cytokine-cytokine receptor interaction | hsa04060 | 4.67 | 2 | AMH, AMHR2 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
TGF-beta signaling pathway (hsa04350) | - | 6.41 | 0.001 | AMH, AMHR2 |
cAMP signaling pathway (hsa04024) | NEW | 5.05 | 0.024 | AMH, AMHR2 |
Cytokine-cytokine receptor interaction (hsa04060) | - | 4.67 | 0.012 | AMH, AMHR2 |
GO | IC | Number of genes with the same GO | Genes |
---|---|---|---|
binding (GO:0005488) | 0.18 | 2 | AMH, AMHR2 |
protein binding (GO:0005515) | 0.46 | 2 | AMH, AMHR2 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
growth factor activity (GO:0008083) | NEW | 4.66 | 0.035 | AMH, AMHR2 |
hormone binding (GO:0042562) | NEW | 5.53 | 0.004 | AMH, AMHR2 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
sex differentiation (GO:0007548) | - | 6.33 | 0.001 | AMH, AMHR2 |
ovulation cycle process (GO:0022602) | NEW | 5.25 | 0.017 | AMH, AMHR2 |
anatomical structure regression (GO:0060033) | - | 7.24 | 0.0 | AMH, AMHR2 |
Mullerian duct regression (GO:0001880) | - | 8.34 | 0.0 | AMH, AMHR2 |