Gene | Associated with WHITE SPONGE NEVUS in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
KRT13 | ClinVar, OMIM, HUMSAVAR | HGNC link | 17q21.2 | 1 | PS193900 |
KRT4 | ClinVar, OMIM, HUMSAVAR | HGNC link | 12q13.13 | 1 | PS193900 |
Download the disease annotation in CSV format
regulated gene | associated to this disease | # TFs | TFs | # TFs associated with this disease | TFs associated with this disease |
---|---|---|---|---|---|
KRT13 | YES | 1 | NR1H4 | 0 | |
KRT4 | YES | 1 | ELF3 | 0 |
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
KRT13 | KRT4 | Yes | 2 | SHC1, CUL3 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct interaction | More information |
---|---|---|---|
KRT13 | KRT4 | yes, complex | They form a heterotetramer of two type I and two type II keratins. Keratin-13 is generally associated with keratin-4. [UniProt] |
GO | IC | Number of genes with the same GO | Genes |
---|---|---|---|
binding (GO:0005488) | 0.18 | 2 | KRT13, KRT4 |
protein binding (GO:0005515) | 0.46 | 2 | KRT13, KRT4 |
structural molecule activity (GO:0005198) | 3.1 | 2 | KRT13, KRT4 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
structural molecule activity (GO:0005198) | - | 3.1 | 0.006 | KRT13, KRT4 |
GO | IC | Number of genes with the same GO | Genes |
---|---|---|---|
organelle organization (GO:0006996) | 2.02 | 2 | KRT13, KRT4 |
cytoskeleton organization (GO:0007010) | 3.22 | 2 | KRT13, KRT4 |
cellular process (GO:0009987) | 0.26 | 2 | KRT13, KRT4 |
cellular component organization (GO:0016043) | 1.24 | 2 | KRT13, KRT4 |
cellular component organization or biogenesis (GO:0071840) | 1.22 | 2 | KRT13, KRT4 |
single-organism process (GO:0044699) | 0.48 | 2 | KRT13, KRT4 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
cytoskeleton organization (GO:0007010) | - | 3.22 | 0.048 | KRT13, KRT4 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
cytoskeleton (GO:0005856) | - | 2.55 | 0.04 | KRT13, KRT4 |
intermediate filament cytoskeleton (GO:0045111) | - | 5.79 | 0.0 | KRT13, KRT4 |
keratin filament (GO:0045095) | - | 5.21 | 0.001 | KRT13, KRT4 |
intermediate filament (GO:0005882) | - | 4.48 | 0.003 | KRT13, KRT4 |