| Disease ID | Disease name | Source of annotation with A2M | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 104300 | ALZHEIMER DISEASE | OMIM | link to OMIM | 13 | HFE, PSEN2, ACE, APBB2, APP, A2M, PAXIP1, NOS3, MPO, PLAU, BLMH, PSEN1, SORL1 |
| 614036 | ALPHA-2-MACROGLOBULIN DEFICIENCY | OMIM | link to OMIM | 1 | A2M |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Complement and coagulation cascades | hsa04610 | 6.58 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Lipoprotein metabolism | R-HSA-174824 | 8.23 |
| Platelet degranulation | R-HSA-114608 | 6.68 |
| Rho GTPase cycle | R-HSA-194840 | 6.04 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 8.52 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 6.11 |
| Extracellular matrix organization | R-HSA-1474244 | 4.91 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Lipid digestion, mobilization, and transport | R-HSA-73923 | 7.2 |
| HDL-mediated lipid transport | R-HSA-194223 | 9.08 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 7.7 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| endopeptidase inhibitor activity | GO:0004866 | 4.6 |
| C-X-C chemokine binding | GO:0019958 | 7.79 |
| calcium-dependent protein binding | GO:0048306 | 5.68 |
| chemokine binding | GO:0019956 | 6.69 |
| cytokine binding | GO:0019955 | 5.21 |
| enzyme binding | GO:0019899 | 2.27 |
| binding | GO:0005488 | 0.18 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| molecular function regulator | GO:0098772 | 2.51 |
| interleukin-8 binding | GO:0019959 | 8.64 |
| growth factor binding | GO:0019838 | 4.89 |
| protease binding | GO:0002020 | 5.08 |
| tumor necrosis factor binding | GO:0043120 | 9.05 |
| endopeptidase regulator activity | GO:0061135 | 4.57 |
| interleukin-1 binding | GO:0019966 | 7.79 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| peptidase regulator activity | GO:0061134 | 4.37 |
| GTPase activator activity | GO:0005096 | 4.11 |
| GTPase regulator activity | GO:0030695 | 4.01 |
| peptidase inhibitor activity | GO:0030414 | 4.55 |
| serine-type endopeptidase inhibitor activity | GO:0004867 | 5.16 |
| nucleoside-triphosphatase regulator activity | GO:0060589 | 3.92 |
| protein binding | GO:0005515 | 0.46 |
| receptor binding | GO:0005102 | 2.43 |
| enzyme activator activity | GO:0008047 | 3.56 |