Gene table of AKT2 : AKT serine/threonine kinase 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with AKT2	OMIM link	Number of associated genes	genes
125853	DIABETES MELLITUS, NONINSULIN-DEPENDENT	ClinVar, OMIM, HUMSAVAR	link to OMIM	33	SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11
240900	HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY	OMIM, HUMSAVAR	link to OMIM	1	AKT2

Download the gene annotation in CSV format

Annotation of the gene AKT2

Associated genes in ENSEMBL

ENSG00000105221

Associated proteins - SwissProt Accession ID

P31751

Associated PDB IDs

Cytogenetic Band

19q13.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Platelet activation	hsa04611	5.66
Progesterone-mediated oocyte maturation	hsa04914	6.18
Small cell lung cancer	hsa05222	6.17
Pancreatic cancer	hsa05212	6.56
Endometrial cancer	hsa05213	6.81
Colorectal cancer	hsa05210	6.52
MAPK signaling pathway	hsa04010	4.63
Jak-STAT signaling pathway	hsa04630	5.44
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Glioma	hsa05214	6.66
Prostate cancer	hsa05215	6.11
Tight junction	hsa04530	5.53
Neurotrophin signaling pathway	hsa04722	5.78
Cholinergic synapse	hsa04725	5.88
Choline metabolism in cancer	hsa05231	6.09
FoxO signaling pathway	hsa04068	5.63
Osteoclast differentiation	hsa04380	5.64
HIF-1 signaling pathway	hsa04066	5.9
Dopaminergic synapse	hsa04728	5.69
Chemokine signaling pathway	hsa04062	5.19
Adipocytokine signaling pathway	hsa04920	6.6
Focal adhesion	hsa04510	4.92
ErbB signaling pathway	hsa04012	6.15
Chagas disease (American trypanosomiasis)	hsa05142	5.99
cGMP-PKG signaling pathway	hsa04022	5.32
Epstein-Barr virus infection	hsa05169	4.97
Toxoplasmosis	hsa05145	5.71
Influenza A	hsa05164	5.21
Apoptosis	hsa04210	6.23
HTLV-I infection	hsa05166	4.59
Hepatitis C	hsa05160	5.68
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
B cell receptor signaling pathway	hsa04662	6.52
Renal cell carcinoma	hsa05211	6.6
VEGF signaling pathway	hsa04370	6.77
Proteoglycans in cancer	hsa05205	5.02
Estrogen signaling pathway	hsa04915	6.11
Toll-like receptor signaling pathway	hsa04620	6.0
Pathways in cancer	hsa05200	3.98
T cell receptor signaling pathway	hsa04660	6.01
Fc gamma R-mediated phagocytosis	hsa04666	6.21
Rap1 signaling pathway	hsa04015	4.97
Ras signaling pathway	hsa04014	4.9
Fc epsilon RI signaling pathway	hsa04664	6.6
cAMP signaling pathway	hsa04024	5.05
Acute myeloid leukemia	hsa05221	6.74
Chronic myeloid leukemia	hsa05220	6.48
TNF signaling pathway	hsa04668	5.96
Thyroid hormone signaling pathway	hsa04919	5.82
AMPK signaling pathway	hsa04152	5.8
mTOR signaling pathway	hsa04150	6.72
PI3K-Akt signaling pathway	hsa04151	4.21
Carbohydrate digestion and absorption	hsa04973	7.28
Non-small cell lung cancer	hsa05223	6.88
Insulin signaling pathway	hsa04910	5.55
Tuberculosis	hsa05152	5.17
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51
Central carbon metabolism in cancer	hsa05230	6.7
Adrenergic signaling in cardiomyocytes	hsa04261	5.44
Prolactin signaling pathway	hsa04917	6.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
GPVI-mediated activation cascade	R-HSA-114604	7.18
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
GAB1 signalosome	R-HSA-180292	6.31
Developmental Biology	R-HSA-1266738	3.48
Generic Transcription Pathway	R-HSA-212436	3.86
IRS-mediated signalling	R-HSA-112399	4.87
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.98
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
Inhibition of TSC complex formation by PKB	R-HSA-165181	11.4
Activation of BH3-only proteins	R-HSA-114452	8.34
Translocation of GLUT4 to the plasma membrane	R-HSA-1445148	6.77
AKT phosphorylates targets in the cytosol	R-HSA-198323	9.28
Signaling by EGFR	R-HSA-177929	4.59
Vesicle-mediated transport	R-HSA-5653656	4.33
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
DAP12 interactions	R-HSA-2172127	4.56
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by ERBB2	R-HSA-1227986	4.66
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.28
PI3K/AKT activation	R-HSA-198203	6.32
Immune System	R-HSA-168256	2.37
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Downstream signal transduction	R-HSA-186763	4.65
AKT phosphorylates targets in the nucleus	R-HSA-198693	9.81
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
CTLA4 inhibitory signaling	R-HSA-389513	8.52
CD28 co-stimulation	R-HSA-389356	7.98
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Innate Immune System	R-HSA-168249	3.17
TCF dependent signaling in response to WNT	R-HSA-201681	5.36
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
Signaling by Wnt	R-HSA-195721	4.79
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	9.28
Signaling by FGFR2	R-HSA-5654738	4.68
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
PI3K Cascade	R-HSA-109704	6.68
PKB-mediated events	R-HSA-109703	7.66
Regulation of gene expression in beta cells	R-HSA-210745	8.66
Transcriptional Regulation by TP53	R-HSA-3700989	6.73
Programmed Cell Death	R-HSA-5357801	5.65
IGF1R signaling cascade	R-HSA-2428924	4.85
deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.59
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
Signaling by Insulin receptor	R-HSA-74752	4.73
Disease	R-HSA-1643685	3.33
Insulin receptor signalling cascade	R-HSA-74751	4.85
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.08
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
Gene Expression	R-HSA-74160	2.72
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
PDE3B signalling	R-HSA-165160	11.98
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Signaling by VEGF	R-HSA-194138	4.66
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
Regulation of beta-cell development	R-HSA-186712	7.98
Activation of AKT2	R-HSA-165158	10.98
mTOR signalling	R-HSA-165159	7.7
Signaling by PDGF	R-HSA-186797	4.53
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.73
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85
Signaling by ERBB4	R-HSA-1236394	4.7
Adaptive Immune System	R-HSA-1280218	3.19
PIP3 activates AKT signaling	R-HSA-1257604	6.37
Platelet activation, signaling and aggregation	R-HSA-76002	5.15
Diseases of signal transduction	R-HSA-5663202	4.89
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.4
AKT-mediated inactivation of FOXO1A	R-HSA-211163	10.98
Costimulation by the CD28 family	R-HSA-388841	6.56
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
Signaling by FGFR	R-HSA-190236	4.67
GPCR downstream signaling	R-HSA-388396	3.07
Signaling by SCF-KIT	R-HSA-1433557	4.73
Membrane Trafficking	R-HSA-199991	5.26
DAP12 signaling	R-HSA-2424491	4.64
Signalling by NGF	R-HSA-166520	4.23
Signaling by GPCR	R-HSA-372790	2.68
G-protein beta:gamma signalling	R-HSA-397795	7.31
Signal Transduction	R-HSA-162582	1.78
Hemostasis	R-HSA-109582	3.98
Apoptosis	R-HSA-109581	5.68

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
protein kinase C binding	GO:0005080	5.83
enzyme binding	GO:0019899	2.27
binding	GO:0005488	0.18
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
ribonucleoside binding	GO:0032549	2.22
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
small molecule binding	GO:0036094	1.89
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
catalytic activity	GO:0003824	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19