| Disease ID | Disease name | Source of annotation with APC | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 114550 | HEPATOCELLULAR CARCINOMA | OMIM | link to OMIM | 11 | CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1 |
| 135290 | DESMOID DISEASE, HEREDITARY | OMIM | link to OMIM | 1 | APC |
| 155255 | MEDULLOBLASTOMA | HUMSAVAR | link to OMIM | 5 | BRCA2, APC, PTCH2, CTNNB1, SUFU |
| 613659 | GASTRIC CANCER | OMIM, HUMSAVAR | link to OMIM | 9 | KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS |
| PS175100 | FAMAILIAL ADENOMATOUS POLYPOSIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 3 | APC, MUTYH, NTHL1 |
| 114500 | COLORECTAL CANCER | ClinVar, OMIM | link to OMIM | 30 | TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 | 5.6 |
| Endometrial cancer | hsa05213 | 6.81 |
| Colorectal cancer | hsa05210 | 6.52 |
| MicroRNAs in cancer | hsa05206 | 5.38 |
| Pathways in cancer | hsa05200 | 3.98 |
| Basal cell carcinoma | hsa05217 | 6.79 |
| Hippo signaling pathway | hsa04390 | 5.37 |
| HTLV-I infection | hsa05166 | 4.59 |
| Wnt signaling pathway | hsa04310 | 5.49 |
| Regulation of actin cytoskeleton | hsa04810 | 4.9 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Apoptotic execution phase | R-HSA-75153 | 7.28 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 7.59 |
| disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 8.03 |
| Disease | R-HSA-1643685 | 3.33 |
| T41 mutants of beta-catenin aren't phosphorylated | R-HSA-5358752 | 9.08 |
| S45 mutants of beta-catenin aren't phosphorylated | R-HSA-5358751 | 9.08 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 7.73 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 8.89 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 9.18 |
| AXIN mutants destabilize the destruction complex, activating WNT signaling | R-HSA-4839735 | 9.18 |
| truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 9.18 |
| Diseases of signal transduction | R-HSA-5663202 | 4.89 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
| AMER1 mutants destabilize the destruction complex | R-HSA-4839748 | 9.18 |
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| misspliced GSK3beta mutants stabilize beta-catenin | R-HSA-5339716 | 9.08 |
| S33 mutants of beta-catenin aren't phosphorylated | R-HSA-5358747 | 9.08 |
| S37 mutants of beta-catenin aren't phosphorylated | R-HSA-5358749 | 9.08 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 6.64 |
| Signaling by WNT in cancer | R-HSA-4791275 | 7.89 |
| truncated APC mutants destabilize the destruction complex | R-HSA-4839744 | 9.18 |
| Apoptosis | R-HSA-109581 | 5.68 |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | R-HSA-4839743 | 9.08 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 12.98 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 9.18 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| tubulin binding | GO:0015631 | 4.1 |
| enzyme binding | GO:0019899 | 2.27 |
| cell adhesion molecule binding | GO:0050839 | 4.5 |
| cadherin binding | GO:0045296 | 6.41 |
| cytoskeletal protein binding | GO:0008092 | 3.02 |
| microtubule binding | GO:0008017 | 4.42 |
| microtubule plus-end binding | GO:0051010 | 7.44 |
| gamma-catenin binding | GO:0045295 | 7.17 |
| beta-catenin binding | GO:0008013 | 5.3 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| protein complex binding | GO:0032403 | 3.09 |
| molecular function regulator | GO:0098772 | 2.51 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| protein kinase regulator activity | GO:0019887 | 4.6 |
| kinase regulator activity | GO:0019207 | 4.5 |