| Disease ID | Disease name | Source of annotation with APOA1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 105200 | AMYLOIDOSIS, FAMILIAL VISCERAL | OMIM, HUMSAVAR | link to OMIM | 4 | APOA1, B2M, FGA, LYZ |
| 604091 | HYPOALPHALIPOPROTEINEMIA, PRIMARY | ClinVar, OMIM | link to OMIM | 2 | APOA1, ABCA1 |
| 205400 | TANGIER DISEASE | ClinVar | link to OMIM | 2 | APOA1, ABCA1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| African trypanosomiasis | hsa05143 | 7.68 |
| PPAR signaling pathway | hsa03320 | 6.56 |
| Fat digestion and absorption | hsa04975 | 7.45 |
| Vitamin digestion and absorption | hsa04977 | 8.24 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Visual phototransduction | R-HSA-2187338 | 6.44 |
| Platelet degranulation | R-HSA-114608 | 6.68 |
| ABC-family proteins mediated transport | R-HSA-382556 | 7.59 |
| Lipid digestion, mobilization, and transport | R-HSA-73923 | 7.2 |
| Transmembrane transport of small molecules | R-HSA-382551 | 3.79 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Fatty acid, triacylglycerol, and ketone body metabolism | R-HSA-535734 | 5.44 |
| Disease | R-HSA-1643685 | 3.33 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| PPARA activates gene expression | R-HSA-1989781 | 6.18 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | R-HSA-400206 | 6.14 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
| Scavenging by Class B Receptors | R-HSA-3000471 | 10.66 |
| Amyloids | R-HSA-977225 | 7.37 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| Chylomicron-mediated lipid transport | R-HSA-174800 | 9.18 |
| Lipoprotein metabolism | R-HSA-174824 | 8.23 |
| HDL-mediated lipid transport | R-HSA-194223 | 9.08 |
| Vesicle-mediated transport | R-HSA-5653656 | 4.33 |
| Scavenging of heme from plasma | R-HSA-2168880 | 5.61 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 5.38 |
| ABC transporters in lipid homeostasis | R-HSA-1369062 | 9.08 |
| Retinoid metabolism and transport | R-HSA-975634 | 7.59 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 8.73 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| cholesterol transporter activity | GO:0017127 | 7.17 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| molecular function regulator | GO:0098772 | 2.51 |
| GO:0060228 | 7.95 | |
| apolipoprotein A-I receptor binding | GO:0034191 | 8.35 |
| apolipoprotein receptor binding | GO:0034190 | 7.79 |
| phospholipid transporter activity | GO:0005548 | 5.87 |
| cation binding | GO:0043169 | 1.4 |
| lipase inhibitor activity | GO:0055102 | 6.85 |
| beta-amyloid binding | GO:0001540 | 6.21 |
| phospholipid binding | GO:0005543 | 3.91 |
| transporter activity | GO:0005215 | 2.57 |
| ion binding | GO:0043167 | 1.36 |
| lipoprotein particle receptor binding | GO:0070325 | 6.65 |
| identical protein binding | GO:0042802 | 2.63 |
| lipid transporter activity | GO:0005319 | 5.03 |
| high-density lipoprotein particle binding | GO:0008035 | 7.66 |
| sterol binding | GO:0032934 | 5.98 |
| amide binding | GO:0033218 | 4.14 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| lipid binding | GO:0008289 | 3.26 |
| small molecule binding | GO:0036094 | 1.89 |
| phosphatidylcholine binding | GO:0031210 | 6.69 |
| enzyme binding | GO:0019899 | 2.27 |
| steroid binding | GO:0005496 | 5.24 |
| peptide binding | GO:0042277 | 4.22 |
| sterol transporter activity | GO:0015248 | 6.85 |
| protein-lipid complex binding | GO:0071814 | 6.56 |
| lipoprotein particle binding | GO:0071813 | 6.56 |
| substrate-specific transporter activity | GO:0022892 | 2.72 |
| cholesterol binding | GO:0015485 | 6.1 |
| alcohol binding | GO:0043178 | 5.53 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| ammonium ion binding | GO:0070405 | 5.81 |
| chemorepellent activity | GO:0045499 | 6.44 |
| protein binding | GO:0005515 | 0.46 |
| GO:0070653 | 8.64 | |
| receptor binding | GO:0005102 | 2.43 |
| enzyme activator activity | GO:0008047 | 3.56 |