Gene table of APOE : apolipoprotein E

Gene-disease associations table

Disease ID	Disease name	Source of annotation with APOE	OMIM link	Number of associated genes	genes
PS603075	MACULAR DEGENERATION, AGE-RELATED	OMIM	link to OMIM	19	RAX2, CFB, ERCC6, TLR4, CFHR3, CFHR1, HMCN1, CFI, CFH, C3, HTRA1, ABCA4, CX3CR1, FBLN5, C2, APOE, CST3, ARMS2, C9
269600	SEA-BLUE HISTIOCYTE DISEASE	OMIM	link to OMIM	1	APOE
608516	MAJOR DEPRESSIVE DISORDER	ClinVar	link to OMIM	4	FKBP5, TPH2, APOE, HTR2A
104310	ALZHEIMER DISEASE 2	ClinVar, OMIM	link to OMIM	1	APOE
611771	LIPOPROTEIN GLOMERULOPATHY	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	APOE

Download the gene annotation in CSV format

Annotation of the gene APOE

Associated genes in ENSEMBL

ENSG00000130203

Associated proteins - SwissProt Accession ID

P02649

Associated PDB IDs

Cytogenetic Band

19q13.32

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Alzheimer's disease	hsa05010	5.34

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Lipoprotein metabolism	R-HSA-174824	8.23
Visual phototransduction	R-HSA-2187338	6.44
Lipid digestion, mobilization, and transport	R-HSA-73923	7.2
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79
Metabolism	R-HSA-1430728	2.34
Signal Transduction	R-HSA-162582	1.78
Retinoid metabolism and transport	R-HSA-975634	7.59
HDL-mediated lipid transport	R-HSA-194223	9.08
Scavenging by Class A Receptors	R-HSA-3000480	8.73
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	5.38
Chylomicron-mediated lipid transport	R-HSA-174800	9.18
Vesicle-mediated transport	R-HSA-5653656	4.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
sterol transporter activity	GO:0015248	6.85
cholesterol transporter activity	GO:0017127	7.17
cholesterol binding	GO:0015485	6.1
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
molecular function regulator	GO:0098772	2.51
	GO:0060228	7.95
sulfur compound binding	GO:1901681	4.32
cation binding	GO:0043169	1.4
	GO:0046911	9.74
peptide binding	GO:0042277	4.22
phospholipid binding	GO:0005543	3.91
transporter activity	GO:0005215	2.57
ion binding	GO:0043167	1.36
very-low-density lipoprotein particle receptor binding	GO:0070326	8.35
lipoprotein particle receptor binding	GO:0070325	6.65
metal ion binding	GO:0046872	1.41
enzyme regulator activity	GO:0030234	2.85
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
lipid transporter activity	GO:0005319	5.03
sterol binding	GO:0032934	5.98
amide binding	GO:0033218	4.14
antioxidant activity	GO:0016209	5.49
lipid binding	GO:0008289	3.26
tau protein binding	GO:0048156	7.25
small molecule binding	GO:0036094	1.89
steroid binding	GO:0005496	5.24
beta-amyloid binding	GO:0001540	6.21
protein dimerization activity	GO:0046983	2.72
low-density lipoprotein particle receptor binding	GO:0050750	6.91
lipoprotein particle binding	GO:0071813	6.56
substrate-specific transporter activity	GO:0022892	2.72
protein-lipid complex binding	GO:0071814	6.56
heparin binding	GO:0008201	4.68
cytoskeletal protein binding	GO:0008092	3.02
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
alcohol binding	GO:0043178	5.53
glycosaminoglycan binding	GO:0005539	4.42
protein binding	GO:0005515	0.46
receptor binding	GO:0005102	2.43
enzyme activator activity	GO:0008047	3.56