| Immune System | R-HSA-168256 | 2.37 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| HIV Infection | R-HSA-162906 | 5.22 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 8.18 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 6.64 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 8.59 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Disease | R-HSA-1643685 | 3.33 |
| Host Interactions of HIV factors | R-HSA-162909 | 5.99 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 5.88 |
| ER-Phagosome pathway | R-HSA-1236974 | 6.08 |
| Endosomal/Vacuolar pathway | R-HSA-1236977 | 6.92 |
| Interferon gamma signaling | R-HSA-877300 | 5.67 |
| Amyloids | R-HSA-977225 | 7.37 |
| Interferon Signaling | R-HSA-913531 | 4.95 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 4.7 |
| Infectious disease | R-HSA-5663205 | 4.47 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 4.65 |
| DAP12 signaling | R-HSA-2424491 | 4.64 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 9.66 |
| DAP12 interactions | R-HSA-2172127 | 4.56 |