| Disease ID | Disease name | Source of annotation with CASP10 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613659 | GASTRIC CANCER | OMIM, HUMSAVAR | link to OMIM | 9 | KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS |
| 603909 | AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | CASP10 |
| 605027 | LYMPHOMA, NON-HODGKIN, FAMILIAL | ClinVar, OMIM, HUMSAVAR | link to OMIM | 7 | BRAF, RAD54B, BCL10, PRF1, CASP10, TP53, RAD54L |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| TNF signaling pathway | hsa04668 | 5.96 |
| Apoptosis | hsa04210 | 6.23 |
| Hepatitis B | hsa05161 | 5.52 |
| RIG-I-like receptor signaling pathway | hsa04622 | 6.62 |
| Tuberculosis | hsa05152 | 5.17 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 9.4 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Immune System | R-HSA-168256 | 2.37 |
| FasL/ CD95L signaling | R-HSA-75157 | 10.66 |
| Death Receptor Signalling | R-HSA-73887 | 8.52 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| TRAIL signaling | R-HSA-75158 | 10.18 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| endopeptidase activity | GO:0004175 | 3.63 |
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| signal transducer activity | GO:0004871 | 2.28 |
| cysteine-type endopeptidase activity involved in apoptotic process | GO:0097153 | 7.03 |
| death effector domain binding | GO:0035877 | 8.35 |
| enzyme binding | GO:0019899 | 2.27 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| catalytic activity | GO:0003824 | 1.05 |
| cysteine-type endopeptidase activity | GO:0004197 | 5.28 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| peptidase activity | GO:0008233 | 3.23 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| cysteine-type peptidase activity | GO:0008234 | 4.51 |
| protein domain specific binding | GO:0019904 | 3.32 |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | GO:0097199 | 9.05 |