| Disease ID | Disease name | Source of annotation with CBL | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613563 | NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | CBL |
| 607785 | JUVENILE MYELOMONOCYTIC LEUKEMIA | ClinVar | link to OMIM | 8 | MLLT11, NF1, ARHGAP26, KRAS, SETBP1, PTPN11, CBL, NRAS |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Bacterial invasion of epithelial cells | hsa05100 | 6.34 |
| Proteoglycans in cancer | hsa05205 | 5.02 |
| Chronic myeloid leukemia | hsa05220 | 6.48 |
| Pathways in cancer | hsa05200 | 3.98 |
| Jak-STAT signaling pathway | hsa04630 | 5.44 |
| T cell receptor signaling pathway | hsa04660 | 6.01 |
| Insulin signaling pathway | hsa04910 | 5.55 |
| Endocytosis | hsa04144 | 4.92 |
| Ubiquitin mediated proteolysis | hsa04120 | 5.63 |
| ErbB signaling pathway | hsa04012 | 6.15 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by Interleukins | R-HSA-449147 | 4.71 |
| Immune System | R-HSA-168256 | 2.37 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 4.62 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Disease | R-HSA-1643685 | 3.33 |
| Regulation of signaling by CBL | R-HSA-912631 | 8.52 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 7.98 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 7.89 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 8.73 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 9.08 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 9.08 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 8.73 |
| Signaling by FGFR4 | R-HSA-5654743 | 4.69 |
| Signaling by FGFR3 | R-HSA-5654741 | 4.69 |
| Regulation of KIT signaling | R-HSA-1433559 | 8.98 |
| Signaling by FGFR | R-HSA-190236 | 4.67 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 9.18 |
| Diseases of signal transduction | R-HSA-5663202 | 4.89 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 6.81 |
| Signaling by SCF-KIT | R-HSA-1433557 | 4.73 |
| Interleukin-3, 5 and GM-CSF signaling | R-HSA-512988 | 4.99 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 8.73 |
| Signaling by EGFR | R-HSA-177929 | 4.59 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 5.6 |
| Interleukin-6 signaling | R-HSA-1059683 | 9.52 |
| EGFR downregulation | R-HSA-182971 | 8.28 |
| Signaling by FGFR2 | R-HSA-5654738 | 4.68 |
| Signaling by FGFR1 | R-HSA-5654736 | 4.69 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 8.03 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 8.12 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 7.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| binding | GO:0005488 | 0.18 |
| SH3 domain binding | GO:0017124 | 4.98 |
| enzyme binding | GO:0019899 | 2.27 |
| zinc ion binding | GO:0008270 | 2.66 |
| signal transducer activity | GO:0004871 | 2.28 |
| protein phosphorylated amino acid binding | GO:0045309 | 6.56 |
| ubiquitin protein ligase activity | GO:0061630 | 4.47 |
| ubiquitin-like protein transferase activity | GO:0019787 | 3.69 |
| cation binding | GO:0043169 | 1.4 |
| transition metal ion binding | GO:0046914 | 2.48 |
| ligase activity | GO:0016874 | 3.72 |
| ion binding | GO:0043167 | 1.36 |
| transferase activity | GO:0016740 | 1.95 |
| calcium ion binding | GO:0005509 | 3.17 |
| metal ion binding | GO:0046872 | 1.41 |
| ephrin receptor binding | GO:0046875 | 6.56 |
| phosphotyrosine binding | GO:0001784 | 7.03 |
| protein kinase binding | GO:0019901 | 3.44 |
| catalytic activity | GO:0003824 | 1.05 |
| protein domain specific binding | GO:0019904 | 3.32 |
| ubiquitin-protein transferase activity | GO:0004842 | 3.73 |
| ubiquitin-like protein ligase activity | GO:0061659 | 4.44 |
| kinase binding | GO:0019900 | 3.32 |
| transcription factor activity, sequence-specific DNA binding | GO:0003700 | 2.65 |
| phosphoprotein binding | GO:0051219 | 5.64 |
| protein binding | GO:0005515 | 0.46 |
| receptor binding | GO:0005102 | 2.43 |
| nucleic acid binding transcription factor activity | GO:0001071 | 2.65 |