Gene table of CDK4 : cyclin dependent kinase 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with CDK4	OMIM link	Number of associated genes	genes
PS155600	MELANOMA, CUTANEOUS MALIGNANT	ClinVar, OMIM, HUMSAVAR	link to OMIM	11	STK11, POT1, BRAF, TERT, PTEN, CDKN2A, MITF, TYR, MC1R, CDK4, XRCC3

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Annotation of the gene CDK4

Associated genes in ENSEMBL

ENSG00000135446

Associated proteins - SwissProt Accession ID

P11802

Associated PDB IDs

Cytogenetic Band

12q14.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
T cell receptor signaling pathway	hsa04660	6.01
Melanoma	hsa05218	6.56
Bladder cancer	hsa05219	7.38
Small cell lung cancer	hsa05222	6.17
Pancreatic cancer	hsa05212	6.56
Cell cycle	hsa04110	5.68
Pathways in cancer	hsa05200	3.98
Viral carcinogenesis	hsa05203	5.08
p53 signaling pathway	hsa04115	6.56
Tight junction	hsa04530	5.53
Non-small cell lung cancer	hsa05223	6.88
Glioma	hsa05214	6.66
Chronic myeloid leukemia	hsa05220	6.48
HTLV-I infection	hsa05166	4.59
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
PI3K-Akt signaling pathway	hsa04151	4.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Oncogene Induced Senescence	R-HSA-2559585	8.03
Mitotic G1-G1/S phases	R-HSA-453279	5.91
Oxidative Stress Induced Senescence	R-HSA-2559580	6.51
Cellular Senescence	R-HSA-2559583	5.7
G1 Phase	R-HSA-69236	7.73
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7
Meiotic recombination	R-HSA-912446	7.25
Cellular responses to stress	R-HSA-2262752	4.56
Cell Cycle	R-HSA-1640170	3.89
S Phase	R-HSA-69242	6.02
Meiosis	R-HSA-1500620	6.59
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.77
Cell Cycle, Mitotic	R-HSA-69278	4.16
Chromatin organization	R-HSA-4839726	5.19
Cyclin D associated events in G1	R-HSA-69231	7.73
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.34
RMTs methylate histone arginines	R-HSA-3214858	7.49
Ubiquitin-dependent degradation of Cyclin D1	R-HSA-69229	7.34
Developmental Biology	R-HSA-1266738	3.48
Chromatin modifying enzymes	R-HSA-3247509	5.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
kinase regulator activity	GO:0019207	4.5
purine ribonucleoside triphosphate binding	GO:0035639	2.22
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	6.21
molecular function regulator	GO:0098772	2.51
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	6.41
cyclin-dependent protein kinase activity	GO:0097472	6.21
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
cyclin binding	GO:0030332	6.74
protein kinase regulator activity	GO:0019887	4.6
enzyme regulator activity	GO:0030234	2.85
ribonucleoside binding	GO:0032549	2.22
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19