Gene table of CIITA : class II major histocompatibility complex transactivator

Gene-disease associations table

Disease ID	Disease name	Source of annotation with CIITA	OMIM link	Number of associated genes	genes
209920	BARE LYMPHOCYTE SYNDROME, TYPE II	OMIM, HUMSAVAR	link to OMIM	5	CIITA, SMAD9, RFXAP, RFX5, RFXANK
180300	RHEUMATOID ARTHRITIS	ClinVar, OMIM	link to OMIM	9	IL10, PTPN22, SLC22A4, PADI4, HLA-DRB1, NFKBIL1, IRF5, CIITA, CD244

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Annotation of the gene CIITA

Associated genes in ENSEMBL

ENSG00000179583

Associated proteins - SwissProt Accession ID

P33076

Associated PDB IDs

Cytogenetic Band

16p13.13

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Influenza A	hsa05164	5.21
Tuberculosis	hsa05152	5.17
Toxoplasmosis	hsa05145	5.71
Primary immunodeficiency	hsa05340	7.52
Antigen processing and presentation	hsa04612	6.04

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Interferon Signaling	R-HSA-913531	4.95
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Interferon gamma signaling	R-HSA-877300	5.67
Immune System	R-HSA-168256	2.37

Associated GO terms for Molecular function

GO term	GO ID	GO IC
protein C-terminus binding	GO:0008022	4.5
activating transcription factor binding	GO:0033613	5.68
purine ribonucleoside triphosphate binding	GO:0035639	2.22
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
transcription coactivator activity	GO:0003713	4.04
transcription cofactor activity	GO:0003712	3.44
nucleotide binding	GO:0000166	1.96
guanyl ribonucleotide binding	GO:0032561	3.73
transferase activity	GO:0016740	1.95
transferase activity, transferring acyl groups	GO:0016746	4.2
purine nucleoside binding	GO:0001883	2.22
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
GTP binding	GO:0005525	3.78
kinase activity	GO:0016301	2.93
transcription factor binding	GO:0008134	3.46
ribonucleoside binding	GO:0032549	2.22
regulatory region nucleic acid binding	GO:0001067	3.03
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
transcription regulatory region DNA binding	GO:0044212	3.03
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
guanyl nucleotide binding	GO:0019001	3.73
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19