Gene table of CTNNB1 : catenin beta 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with CTNNB1	OMIM link	Number of associated genes	genes
114550	HEPATOCELLULAR CARCINOMA	ClinVar, OMIM	link to OMIM	11	CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1
132600	PILOMATRIXOMA	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	MUTYH, CTNNB1
PS156200	MENTAL RETARDATION, AUTOSOMAL DOMINANT	ClinVar, OMIM, HUMSAVAR	link to OMIM	44	EHMT1, MEF2C, AHDC1, SOX11, CDH15, KIRREL3, EEF1A2, KAT6A, ZMYND11, ARID1A, KMT2C, PPP2R5D, DYNC1H1, GRIN1, CTCF, SETD5, NR1I3, PACS1, DPP6, DEAF1, KIF1A, SYNGAP1, PURA, POGZ, EPB41L1, PPP2R1A, AUTS2, CTNNB1, ARID1B, ZBTB18, CACNG2, MBD5, SMARCB1, KANSL1, SMARCE1, COL4A3BP, MYT1L, ADNP, SMARCA4, GATAD2B, SETBP1, GRIN2B, CHAMP1, DYRK1A
155255	MEDULLOBLASTOMA	ClinVar, HUMSAVAR	link to OMIM	5	APC, BRCA2, CTNNB1, PTCH2, SUFU
114500	COLORECTAL CANCER	OMIM, HUMSAVAR	link to OMIM	30	TLR4, RAD54B, PTPRJ, MLH3, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, TP53, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B
167000	OVARIAN CANCER	OMIM, HUMSAVAR	link to OMIM	9	AKT1, PARK2, CTNNB1, CDH1, BRCA1, RRAS2, PIK3CA, OPCML, SEPT9

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Annotation of the gene CTNNB1

Associated genes in ENSEMBL

ENSG00000168036

Associated proteins - SwissProt Accession ID

P35222

Associated PDB IDs

Cytogenetic Band

3p22.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Pathogenic Escherichia coli infection	hsa05130	6.99
Basal cell carcinoma	hsa05217	6.79
Bacterial invasion of epithelial cells	hsa05100	6.34
Proteoglycans in cancer	hsa05205	5.02
Endometrial cancer	hsa05213	6.81
Colorectal cancer	hsa05210	6.52
Thyroid cancer	hsa05216	7.48
Pathways in cancer	hsa05200	3.98
Prostate cancer	hsa05215	6.11
Tight junction	hsa04530	5.53
Rap1 signaling pathway	hsa04015	4.97
Leukocyte transendothelial migration	hsa04670	5.74
Melanogenesis	hsa04916	5.97
Adherens junction	hsa04520	6.26
Focal adhesion	hsa04510	4.92
Hippo signaling pathway	hsa04390	5.37
HTLV-I infection	hsa05166	4.59
Thyroid hormone signaling pathway	hsa04919	5.82
Wnt signaling pathway	hsa04310	5.49
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Immune System	R-HSA-168256	2.37
Signaling by Rho GTPases	R-HSA-194315	4.43
Apoptotic execution phase	R-HSA-75153	7.28
Programmed Cell Death	R-HSA-5357801	5.65
Peptide hormone metabolism	R-HSA-2980736	6.61
deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.59
CDO in myogenesis	R-HSA-375170	8.12
disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.03
Adherens junctions interactions	R-HSA-418990	7.98
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.66
binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	10.18
Developmental Biology	R-HSA-1266738	3.48
repression of WNT target genes	R-HSA-4641265	9.28
T41 mutants of beta-catenin aren't phosphorylated	R-HSA-5358752	9.08
S45 mutants of beta-catenin aren't phosphorylated	R-HSA-5358751	9.08
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73
Beta-catenin phosphorylation cascade	R-HSA-196299	8.89
Cell-cell junction organization	R-HSA-421270	7.03
Ca2+ pathway	R-HSA-4086398	7.1
Disease	R-HSA-1643685	3.33
Myogenesis	R-HSA-525793	8.12
RHO GTPases activate IQGAPs	R-HSA-5626467	8.34
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
Diseases of signal transduction	R-HSA-5663202	4.89
beta-catenin independent WNT signaling	R-HSA-3858494	5.83
Innate Immune System	R-HSA-168249	3.17
Cell junction organization	R-HSA-446728	6.51
Metabolism of proteins	R-HSA-392499	3.41
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	10.66
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.46
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.28
Cell-Cell communication	R-HSA-1500931	5.87
RHO GTPase Effectors	R-HSA-195258	4.94
Signaling by Wnt	R-HSA-195721	4.79
formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.18
misspliced GSK3beta mutants stabilize beta-catenin	R-HSA-5339716	9.08
S33 mutants of beta-catenin aren't phosphorylated	R-HSA-5358747	9.08
S37 mutants of beta-catenin aren't phosphorylated	R-HSA-5358749	9.08
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.64
Signaling by WNT in cancer	R-HSA-4791275	7.89
Signaling by VEGF	R-HSA-194138	4.66
Apoptosis	R-HSA-109581	5.68
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	R-HSA-4839743	9.08
TCF dependent signaling in response to WNT	R-HSA-201681	5.36
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	9.52
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
protein C-terminus binding	GO:0008022	4.5
signal transducer activity	GO:0004871	2.28
activating transcription factor binding	GO:0033613	5.68
androgen receptor binding	GO:0050681	6.07
enzyme binding	GO:0019899	2.27
euchromatin binding	GO:1990188	9.05
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
ion channel binding	GO:0044325	5.02
heterocyclic compound binding	GO:1901363	1.06
repressing transcription factor binding	GO:0070491	5.71
transcription coactivator activity	GO:0003713	4.04
transcription cofactor activity	GO:0003712	3.44
SMAD binding	GO:0046332	5.45
transcription factor activity, transcription factor binding	GO:0000989	3.36
I-SMAD binding	GO:0070411	7.34
protein complex binding	GO:0032403	3.09
double-stranded DNA binding	GO:0003690	3.09
steroid hormone receptor binding	GO:0035258	5.32
estrogen receptor binding	GO:0030331	6.05
transcription regulatory region DNA binding	GO:0044212	3.03
regulatory region nucleic acid binding	GO:0001067	3.03
transcription factor binding	GO:0008134	3.46
transcription factor activity, protein binding	GO:0000988	3.35
nuclear hormone receptor binding	GO:0035257	4.7
ionotropic glutamate receptor binding	GO:0035255	6.56
glutamate receptor binding	GO:0035254	6.13
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
RNA polymerase II activating transcription factor binding	GO:0001102	6.13
hormone receptor binding	GO:0051427	4.57
cell adhesion molecule binding	GO:0050839	4.5
RNA polymerase II transcription factor binding	GO:0001085	5.08
nitric-oxide synthase binding	GO:0050998	6.91
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
alpha-catenin binding	GO:0045294	7.44
cadherin binding	GO:0045296	6.41
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
receptor binding	GO:0005102	2.43
chromatin binding	GO:0003682	3.64
nucleic acid binding transcription factor activity	GO:0001071	2.65