| Disease ID | Disease name | Source of annotation with CTSK | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 265800 | PYCNODYSOSTOSIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | CTSK |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Rheumatoid arthritis | hsa05323 | 6.05 |
| Lysosome | hsa04142 | 5.78 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| Osteoclast differentiation | hsa04380 | 5.64 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Activation of Matrix Metalloproteinases | R-HSA-1592389 | 8.03 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Immune System | R-HSA-168256 | 2.37 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 6.11 |
| Collagen degradation | R-HSA-1442490 | 7.03 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 9.28 |
| Extracellular matrix organization | R-HSA-1474244 | 4.91 |
| MHC class II antigen presentation | R-HSA-2132295 | 6.01 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| GO term | GO ID | GO IC |
|---|---|---|
| glycoprotein binding | GO:0001948 | 5.11 |
| hydrolase activity | GO:0016787 | 1.9 |
| endopeptidase activity | GO:0004175 | 3.63 |
| serine-type endopeptidase activity | GO:0004252 | 4.4 |
| serine hydrolase activity | GO:0017171 | 4.26 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| proteoglycan binding | GO:0043394 | 6.34 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| catalytic activity | GO:0003824 | 1.05 |
| cysteine-type endopeptidase activity | GO:0004197 | 5.28 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| protein complex binding | GO:0032403 | 3.09 |
| peptidase activity | GO:0008233 | 3.23 |
| collagen binding | GO:0005518 | 5.58 |
| cysteine-type peptidase activity | GO:0008234 | 4.51 |
| fibronectin binding | GO:0001968 | 6.41 |
| serine-type peptidase activity | GO:0008236 | 4.27 |