| Disease ID | Disease name | Source of annotation with CYP2A6 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 122700 | COUMARIN RESISTANCE | OMIM | link to OMIM | 4 | CYP2A6, F9, CYP2C9, VKORC1 |
| 211980 | LUNG CANCER | OMIM | link to OMIM | 17 | RASSF1, PARK2, IRF1, CASP8, ERBB2, PPP2R1B, FASLG, MAP3K8, PIK3CA, BRAF, KRAS, DLEC1, SLC22A18, ERCC6, CYP2A6, MXRA5, EGFR |
| 188890 | TOBACCO ADDICTION, SUSCEPTIBILITY TO | OMIM | link to OMIM | 4 | SLC6A3, CYP2A6, GABBR2, CHRNA4 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 | 6.48 |
| Drug metabolism - other enzymes | hsa00983 | 7.21 |
| Drug metabolism - cytochrome P450 | hsa00982 | 6.6 |
| Retinol metabolism | hsa00830 | 6.79 |
| Metabolic pathways | hsa01100 | 2.49 |
| Caffeine metabolism | hsa00232 | 10.45 |
| Chemical carcinogenesis | hsa05204 | 6.36 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Xenobiotics | R-HSA-211981 | 8.66 |
| Biological oxidations | R-HSA-211859 | 5.55 |
| CYP2E1 reactions | R-HSA-211999 | 9.52 |
| Cytochrome P450 - arranged by substrate type | R-HSA-211897 | 7.08 |
| Phase 1 - Functionalization of compounds | R-HSA-211945 | 6.7 |
| Metabolism | R-HSA-1430728 | 2.34 |
| GO term | GO ID | GO IC |
|---|---|---|
| oxidoreductase activity | GO:0016491 | 3.12 |
| cation binding | GO:0043169 | 1.4 |
| monooxygenase activity | GO:0004497 | 5.1 |
| metal ion binding | GO:0046872 | 1.41 |
| transition metal ion binding | GO:0046914 | 2.48 |
| heme binding | GO:0020037 | 4.86 |
| tetrapyrrole binding | GO:0046906 | 4.8 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | GO:0016705 | 4.65 |
| enzyme binding | GO:0019899 | 2.27 |
| ion binding | GO:0043167 | 1.36 |
| catalytic activity | GO:0003824 | 1.05 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | GO:0016712 | 6.37 |
| coumarin 7-hydroxylase activity | GO:0008389 | 9.05 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| iron ion binding | GO:0005506 | 4.65 |
| steroid hydroxylase activity | GO:0008395 | 6.3 |
| arachidonic acid epoxygenase activity | GO:0008392 | 7.03 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| arachidonic acid monooxygenase activity | GO:0008391 | 7.03 |