Gene table of DNMT1 : DNA methyltransferase 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with DNMT1	OMIM link	Number of associated genes	genes
604121	CEREBELLAR ATAXIA, DEAFNESS, AND NARCOLEPSY, AUTOSOMAL DOMINANT	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	DNMT1
PS162400	HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY	ClinVar, OMIM, HUMSAVAR	link to OMIM	14	DST, WNK1, NTRK1, PRDM12, DNMT1, IKBKAP, FAM134B, NGF, ATL1, KIF1A, SCN11A, ATL3, SPTLC2, SPTLC1

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Annotation of the gene DNMT1

Associated genes in ENSEMBL

ENSG00000130816

Associated proteins - SwissProt Accession ID

P26358

Associated PDB IDs

Cytogenetic Band

19p13.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Metabolic pathways	hsa01100	2.49
Cysteine and methionine metabolism	hsa00270	7.56
MicroRNAs in cancer	hsa05206	5.38

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.75
DNA methylation	R-HSA-5334118	8.03
NoRC negatively regulates rRNA expression	R-HSA-427413	6.81
Epigenetic regulation of gene expression	R-HSA-212165	6.46
PRC2 methylates histones and DNA	R-HSA-212300	7.7
Gene Expression	R-HSA-74160	2.72

Associated GO terms for Molecular function

GO term	GO ID	GO IC
heterocyclic compound binding	GO:1901363	1.06
enzyme binding	GO:0019899	2.27
unmethylated CpG binding	GO:0045322	7.95
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
methyltransferase activity	GO:0008168	4.35
nucleotide binding	GO:0000166	1.96
DNA-methyltransferase activity	GO:0009008	8.13
nucleoside phosphate binding	GO:1901265	1.96
sequence-specific DNA binding	GO:0043565	2.79
transition metal ion binding	GO:0046914	2.48
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	GO:0051718	8.64
ion binding	GO:0043167	1.36
DNA (cytosine-5-)-methyltransferase activity	GO:0003886	8.35
transferase activity	GO:0016740	1.95
transferase activity, transferring one-carbon groups	GO:0016741	4.3
double-stranded DNA binding	GO:0003690	3.09
metal ion binding	GO:0046872	1.41
histone deacetylase binding	GO:0042826	5.08
steroid hormone receptor binding	GO:0035258	5.32
estrogen receptor binding	GO:0030331	6.05
cation binding	GO:0043169	1.4
methyl-CpG binding	GO:0008327	6.69
S-adenosylmethionine-dependent methyltransferase activity	GO:0008757	4.81
nuclear hormone receptor binding	GO:0035257	4.7
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
protein domain specific binding	GO:0019904	3.32
hormone receptor binding	GO:0051427	4.57
promoter-specific chromatin binding	GO:1990841	7.34
organic cyclic compound binding	GO:0097159	1.05
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
receptor binding	GO:0005102	2.43
chromatin binding	GO:0003682	3.64
zinc ion binding	GO:0008270	2.66