Gene table of DRD2 : dopamine receptor D2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with DRD2	OMIM link	Number of associated genes	genes
PS128100	DYSTONIA	ClinVar	link to OMIM	18	DRD2, GNAL, ANO3, SLC2A1, KCTD17, HPCA, THAP1, GCH1, PRRT2, ATP1A3, PNKD, PRKRA, COL6A3, TOR1A, CACNA1B, SGCE, TAF1, TUBB4A

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Gap junction	hsa04540	6.24
Cocaine addiction	hsa05030	7.07
cAMP signaling pathway	hsa04024	5.05
Rap1 signaling pathway	hsa04015	4.97
Alcoholism	hsa05034	5.59
Dopaminergic synapse	hsa04728	5.69
Neuroactive ligand-receptor interaction	hsa04080	4.58
Parkinson's disease	hsa05012	5.59

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Amine ligand-binding receptors	R-HSA-375280	7.59
Signaling by GPCR	R-HSA-372790	2.68
G alpha (i) signalling events	R-HSA-418594	5.1
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69
Signal Transduction	R-HSA-162582	1.78
GPCR downstream signaling	R-HSA-388396	3.07
GPCR ligand binding	R-HSA-500792	4.19
Dopamine receptors	R-HSA-390651	10.66

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
drug binding	GO:0008144	5.03
molecular transducer activity	GO:0060089	2.32
dopamine neurotransmitter receptor activity	GO:0004952	7.79
dopamine binding	GO:0035240	7.34
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
molecular function regulator	GO:0098772	2.51
G-protein coupled receptor activity	GO:0004930	2.95
adrenergic receptor activity	GO:0004935	6.97
G-protein coupled amine receptor activity	GO:0008227	5.83
channel regulator activity	GO:0016247	4.88
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
neurotransmitter receptor activity	GO:0030594	5.5
potassium channel regulator activity	GO:0015459	5.93
ionotropic glutamate receptor binding	GO:0035255	6.56
glutamate receptor binding	GO:0035254	6.13
protein dimerization activity	GO:0046983	2.72
organic cyclic compound binding	GO:0097159	1.05
dopamine neurotransmitter receptor activity, coupled via Gi/Go	GO:0001591	8.64
transmembrane signaling receptor activity	GO:0004888	2.57
protein binding	GO:0005515	0.46
catecholamine binding	GO:1901338	6.97
receptor binding	GO:0005102	2.43
protein heterodimerization activity	GO:0046982	3.64
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32