Gene table of EZH2 : enhancer of zeste 2 polycomb repressive complex 2 subunit

Gene-disease associations table

Disease ID	Disease name	Source of annotation with EZH2	OMIM link	Number of associated genes	genes
277590	WEAVER SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	EZH2

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
MicroRNAs in cancer	hsa05206	5.38

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Oxidative Stress Induced Senescence	R-HSA-2559580	6.51
Cellular Senescence	R-HSA-2559583	5.7
Epigenetic regulation of gene expression	R-HSA-212165	6.46
PRC2 methylates histones and DNA	R-HSA-212300	7.7
Cellular responses to stress	R-HSA-2262752	4.56
Chromatin organization	R-HSA-4839726	5.19
PKMTs methylate histone lysines	R-HSA-3214841	7.66
Gene Expression	R-HSA-74160	2.72
Chromatin modifying enzymes	R-HSA-3247509	5.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
histone-lysine N-methyltransferase activity	GO:0018024	5.93
histone methyltransferase activity	GO:0042054	5.68
nucleic acid binding	GO:0003676	1.44
lysine N-methyltransferase activity	GO:0016278	5.7
protein-lysine N-methyltransferase activity	GO:0016279	5.71
chromatin DNA binding	GO:0031490	5.37
protein methyltransferase activity	GO:0008276	5.33
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
histone methyltransferase activity (H3-K27 specific)	GO:0046976	8.64
DNA binding	GO:0003677	1.92
methyltransferase activity	GO:0008168	4.35
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
structure-specific DNA binding	GO:0043566	4.98
transferase activity	GO:0016740	1.95
transferase activity, transferring one-carbon groups	GO:0016741	4.3
ribonucleoprotein complex binding	GO:0043021	5.15
S-adenosylmethionine-dependent methyltransferase activity	GO:0008757	4.81
regulatory region nucleic acid binding	GO:0001067	3.03
catalytic activity	GO:0003824	1.05
N-methyltransferase activity	GO:0008170	5.26
core promoter binding	GO:0001047	4.71
promoter-specific chromatin binding	GO:1990841	7.34
transcription regulatory region DNA binding	GO:0044212	3.03
organic cyclic compound binding	GO:0097159	1.05
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
chromatin binding	GO:0003682	3.64