Gene table of FGFR1 : fibroblast growth factor receptor 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with FGFR1	OMIM link	Number of associated genes	genes
615465	HARTSFIELD SYNDROME	OMIM, HUMSAVAR	link to OMIM	1	FGFR1
101600	PFEIFFER SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	FGFR1, FGFR2
166250	OSTEOGLOPHONIC DYSPLASIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	FGFR1
PS190440	TRIGONOCEPHALY, ISOLATED	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	FGFR1, FREM1
123150	JACKSON-WEISS SYNDROME	ClinVar, OMIM	link to OMIM	2	FGFR1, FGFR2
PS147950	HYPOGONADOTROPIC HYPOGONADISM WITH OR WITHOUT ANOSMIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	24	TAC3, FGFR1, PROKR2, NSMF, WDR11, HS6ST1, TACR3, KISS1, FEZF1, KISS1R, DUSP6, SEMA3A, FGF17, ANOS1, FSHB, CHD7, FGF8, PROK2, FLRT3, GNRHR, IL17RD, SPRY4, GNRH1, LHB
613001	ENCEPHALOCRANIOCUTANEOUS LIPOMATOSIS	ClinVar, OMIM	link to OMIM	1	FGFR1

Download the gene annotation in CSV format

Annotation of the gene FGFR1

Associated genes in ENSEMBL

ENSG00000077782

Associated proteins - SwissProt Accession ID

P11362

Associated PDB IDs

Cytogenetic Band

8p11.23

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Proteoglycans in cancer	hsa05205	5.02
Pathways in cancer	hsa05200	3.98
Prostate cancer	hsa05215	6.11
Rap1 signaling pathway	hsa04015	4.97
Ras signaling pathway	hsa04014	4.9
Central carbon metabolism in cancer	hsa05230	6.7
MAPK signaling pathway	hsa04010	4.63
Adherens junction	hsa04520	6.26
Regulation of actin cytoskeleton	hsa04810	4.9
Melanoma	hsa05218	6.56
PI3K-Akt signaling pathway	hsa04151	4.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Interleukin-2 signaling	R-HSA-451927	5.05
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
GAB1 signalosome	R-HSA-180292	6.31
Developmental Biology	R-HSA-1266738	3.48
Signaling by VEGF	R-HSA-194138	4.66
FCERI mediated MAPK activation	R-HSA-2871796	4.32
IRS-mediated signalling	R-HSA-112399	4.87
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
L1CAM interactions	R-HSA-373760	6.19
Signaling by FGFR1 in disease	R-HSA-5655302	7.81
Signaling by EGFR	R-HSA-177929	4.59
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
DAP12 interactions	R-HSA-2172127	4.56
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by ERBB2	R-HSA-1227986	4.66
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07
PI3K/AKT activation	R-HSA-198203	6.32
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15
Frs2-mediated activation	R-HSA-170968	5.12
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Downstream signal transduction	R-HSA-186763	4.65
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14
Signaling by FGFR1 amplification mutants	R-HSA-1839120	12.98
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Signaling by activated point mutants of FGFR1	R-HSA-1839122	9.52
FGFR1 mutant receptor activation	R-HSA-1839124	8.12
Signaling by FGFR in disease	R-HSA-1226099	7.49
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Interleukin receptor SHC signaling	R-HSA-912526	5.09
Innate Immune System	R-HSA-168249	3.17
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
Prolonged ERK activation events	R-HSA-169893	5.11
Signaling by FGFR2	R-HSA-5654738	4.68
GRB2 events in EGFR signaling	R-HSA-179812	5.15
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
PI3K Cascade	R-HSA-109704	6.68
Axon guidance	R-HSA-422475	3.93
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
FGFR1 ligand binding and activation	R-HSA-190242	8.98
Signaling by Leptin	R-HSA-2586552	5.1
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05
IGF1R signaling cascade	R-HSA-2428924	4.85
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
Signaling by Insulin receptor	R-HSA-74752	4.73
Disease	R-HSA-1643685	3.33
Insulin receptor signalling cascade	R-HSA-74751	4.85
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	11.4
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
FGFR1c ligand binding and activation	R-HSA-190373	9.4
FGFR1b ligand binding and activation	R-HSA-190370	10.4
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.59
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.98
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
Immune System	R-HSA-168256	2.37
Signalling to RAS	R-HSA-167044	5.08
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
SHC1 events in EGFR signaling	R-HSA-180336	5.15
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15
ARMS-mediated activation	R-HSA-170984	5.12
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15
Signaling by PDGF	R-HSA-186797	4.53
Signal transduction by L1	R-HSA-445144	8.59
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85
Signaling by Interleukins	R-HSA-449147	4.71
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
SOS-mediated signalling	R-HSA-112412	5.15
Signaling by ERBB4	R-HSA-1236394	4.7
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11
Adaptive Immune System	R-HSA-1280218	3.19
MAPK family signaling cascades	R-HSA-5683057	4.89
PIP3 activates AKT signaling	R-HSA-1257604	6.37
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.43
RAF/MAP kinase cascade	R-HSA-5673001	5.15
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
Signaling by FGFR	R-HSA-190236	4.67
Signaling by SCF-KIT	R-HSA-1433557	4.73
NCAM signaling for neurite out-growth	R-HSA-375165	4.9
DAP12 signaling	R-HSA-2424491	4.64
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99
Signalling by NGF	R-HSA-166520	4.23
Signaling by GPCR	R-HSA-372790	2.68
Signalling to ERKs	R-HSA-187687	5.04
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
Ras guanyl-nucleotide exchange factor activity	GO:0005088	4.31
signaling receptor activity	GO:0038023	2.49
phosphatidylinositol 3-kinase activity	GO:0035004	5.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
guanyl-nucleotide exchange factor activity	GO:0005085	4.02
molecular transducer activity	GO:0060089	2.32
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
molecular function regulator	GO:0098772	2.51
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	5.61
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
growth factor binding	GO:0019838	4.89
nucleotide binding	GO:0000166	1.96
phosphatidylinositol bisphosphate kinase activity	GO:0052813	5.56
transferase activity	GO:0016740	1.95
identical protein binding	GO:0042802	2.63
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
protein homodimerization activity	GO:0042803	3.16
sulfur compound binding	GO:1901681	4.32
kinase activity	GO:0016301	2.93
protein binding	GO:0005515	0.46
1-phosphatidylinositol-3-kinase activity	GO:0016303	5.98
ribonucleoside binding	GO:0032549	2.22
purine nucleoside binding	GO:0001883	2.22
fibroblast growth factor binding	GO:0017134	6.52
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cell adhesion molecule binding	GO:0050839	4.5
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
heparin binding	GO:0008201	4.68
glycoprotein binding	GO:0001948	5.11
adenyl nucleotide binding	GO:0030554	2.4
phosphatidylinositol kinase activity	GO:0052742	5.81
organic cyclic compound binding	GO:0097159	1.05
glycosaminoglycan binding	GO:0005539	4.42
carbohydrate derivative binding	GO:0097367	2.03
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
fibroblast growth factor-activated receptor activity	GO:0005007	8.13
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32