| Disease ID | Disease name | Source of annotation with GCGR | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 125853 | DIABETES MELLITUS, NONINSULIN-DEPENDENT | ClinVar, OMIM | link to OMIM | 33 | SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 6.52 |
| Glucagon-type ligand receptors | R-HSA-420092 | 8.08 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| Integration of energy metabolism | R-HSA-163685 | 6.24 |
| G alpha (q) signalling events | R-HSA-416476 | 5.42 |
| Metabolism | R-HSA-1430728 | 2.34 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| G alpha (s) signalling events | R-HSA-418555 | 5.99 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 7.94 |
| GO term | GO ID | GO IC |
|---|---|---|
| peptide hormone binding | GO:0017046 | 6.13 |
| G-protein coupled peptide receptor activity | GO:0008528 | 4.86 |
| G-protein coupled receptor activity | GO:0004930 | 2.95 |
| signaling receptor activity | GO:0038023 | 2.49 |
| amide binding | GO:0033218 | 4.14 |
| guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| peptide receptor activity | GO:0001653 | 4.84 |
| receptor activity | GO:0004872 | 2.32 |
| signal transducer activity | GO:0004871 | 2.28 |
| peptide binding | GO:0042277 | 4.22 |
| glucagon receptor activity | GO:0004967 | 8.64 |
| molecular function regulator | GO:0098772 | 2.51 |
| hormone binding | GO:0042562 | 5.53 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| binding | GO:0005488 | 0.18 |