| Disease ID | Disease name | Source of annotation with HADH | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS256450 | HYPERINSULINEMIA HYPOGLYCEMIA | ClinVar, OMIM, HUMSAVAR | link to OMIM | 7 | GCK, INSR, SLC16A1, GLUD1, HADH, ABCC8, KCNJ11 |
| 231530 | 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY | OMIM, HUMSAVAR | link to OMIM | 1 | HADH |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Lysine degradation | hsa00310 | 7.01 |
| Fatty acid elongation | hsa00062 | 8.18 |
| Metabolic pathways | hsa01100 | 2.49 |
| Fatty acid degradation | hsa00071 | 7.15 |
| Valine, leucine and isoleucine degradation | hsa00280 | 7.09 |
| Tryptophan metabolism | hsa00380 | 7.34 |
| Fatty acid metabolism | hsa01212 | 7.07 |
| Butanoate metabolism | hsa00650 | 7.96 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Mitochondrial Fatty Acid Beta-Oxidation | R-HSA-77289 | 9.08 |
| Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | R-HSA-77346 | 10.66 |
| Beta oxidation of butanoyl-CoA to acetyl-CoA | R-HSA-77352 | 11.4 |
| Beta oxidation of hexanoyl-CoA to butanoyl-CoA | R-HSA-77350 | 10.66 |
| Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | R-HSA-77310 | 10.66 |
| Beta oxidation of octanoyl-CoA to hexanoyl-CoA | R-HSA-77348 | 10.66 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | R-HSA-77286 | 9.98 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Fatty acid, triacylglycerol, and ketone body metabolism | R-HSA-535734 | 5.44 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| GO term | GO ID | GO IC |
|---|---|---|
| coenzyme binding | GO:0050662 | 4.53 |
| oxidoreductase activity, acting on CH-OH group of donors | GO:0016614 | 4.83 |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | GO:0016616 | 5.0 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| nucleotide binding | GO:0000166 | 1.96 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| cofactor binding | GO:0048037 | 4.16 |
| binding | GO:0005488 | 0.18 |
| NAD+ binding | GO:0070403 | 7.17 |
| NAD binding | GO:0051287 | 5.77 |
| 3-hydroxyacyl-CoA dehydrogenase activity | GO:0003857 | 7.54 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| oxidoreductase activity | GO:0016491 | 3.12 |