| Disease ID | Disease name | Source of annotation with IL6 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 148000 | KAPOSI SARCOMA, SUSCEPTIBILITY TO | OMIM | link to OMIM | 1 | IL6 |
| 604302 | RHEUMATOID ARTHRITIS, SYSTEMIC JUVENILE | OMIM | link to OMIM | 2 | MIF, IL6 |
| 125853 | DIABETES MELLITUS, NONINSULIN-DEPENDENT | ClinVar, OMIM | link to OMIM | 33 | SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11 |
| 108010 | ARTERIOVENOUS MALFORMATIONS OF THE BRAIN | OMIM | link to OMIM | 1 | IL6 |
| PS266600 | INFLAMMATORY BOWEL DISEASE | OMIM | link to OMIM | 10 | ATG16L1, IL10RB, IRGM, IL10RA, NOD2, IRF5, IL23R, ABCB1, SLC22A5, IL6 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pertussis | hsa05133 | 6.46 |
| Salmonella infection | hsa05132 | 6.29 |
| Legionellosis | hsa05134 | 6.88 |
| Graft-versus-host disease | hsa05332 | 6.84 |
| Intestinal immune network for IgA production | hsa04672 | 6.79 |
| FoxO signaling pathway | hsa04068 | 5.63 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 | 6.21 |
| Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| African trypanosomiasis | hsa05143 | 7.68 |
| Amoebiasis | hsa05146 | 5.82 |
| Prion diseases | hsa05020 | 7.48 |
| Malaria | hsa05144 | 7.15 |
| Influenza A | hsa05164 | 5.21 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Pathways in cancer | hsa05200 | 3.98 |
| Hepatitis B | hsa05161 | 5.52 |
| Measles | hsa05162 | 5.6 |
| Rheumatoid arthritis | hsa05323 | 6.05 |
| Inflammatory bowel disease (IBD) | hsa05321 | 6.43 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| NOD-like receptor signaling pathway | hsa04621 | 6.88 |
| Cytosolic DNA-sensing pathway | hsa04623 | 6.79 |
| HIF-1 signaling pathway | hsa04066 | 5.9 |
| Hematopoietic cell lineage | hsa04640 | 6.18 |
| TNF signaling pathway | hsa04668 | 5.96 |
| Jak-STAT signaling pathway | hsa04630 | 5.44 |
| HTLV-I infection | hsa05166 | 4.59 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
| PI3K-Akt signaling pathway | hsa04151 | 4.21 |
| Transcriptional misregulation in cancer | hsa05202 | 5.21 |
| Tuberculosis | hsa05152 | 5.17 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Interleukin-6 signaling | R-HSA-1059683 | 9.52 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.89 |
| Cellular Senescence | R-HSA-2559583 | 5.7 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 6.77 |
| Signaling by Interleukins | R-HSA-449147 | 4.71 |
| Immune System | R-HSA-168256 | 2.37 |
| Cellular responses to stress | R-HSA-2262752 | 4.56 |
| MAPK1 (ERK2) activation | R-HSA-112411 | 9.81 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 5.11 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 9.66 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.46 |
| GO term | GO ID | GO IC |
|---|---|---|
| cytokine receptor binding | GO:0005126 | 4.14 |
| cytokine activity | GO:0005125 | 4.34 |
| growth factor activity | GO:0008083 | 4.66 |
| growth factor receptor binding | GO:0070851 | 4.87 |
| interleukin-6 receptor binding | GO:0005138 | 7.79 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| receptor binding | GO:0005102 | 2.43 |