| Disease ID | Disease name | Source of annotation with IL6R | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 614752 | INTERLEUKIN 6, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS | ClinVar, OMIM | link to OMIM | 1 | IL6R |
| 614689 | SOLUBLE INTERLEUKIN-6 RECEPTOR, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS | ClinVar, OMIM | link to OMIM | 1 | IL6R |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Jak-STAT signaling pathway | hsa04630 | 5.44 |
| Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
| Hematopoietic cell lineage | hsa04640 | 6.18 |
| HIF-1 signaling pathway | hsa04066 | 5.9 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
| PI3K-Akt signaling pathway | hsa04151 | 4.21 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Interleukin-6 signaling | R-HSA-1059683 | 9.52 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.89 |
| Signaling by Interleukins | R-HSA-449147 | 4.71 |
| Immune System | R-HSA-168256 | 2.37 |
| MAPK1 (ERK2) activation | R-HSA-112411 | 9.81 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 5.11 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 9.66 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.46 |
| GO term | GO ID | GO IC |
|---|---|---|
| cytokine receptor binding | GO:0005126 | 4.14 |
| signaling receptor activity | GO:0038023 | 2.49 |
| cytokine binding | GO:0019955 | 5.21 |
| enzyme binding | GO:0019899 | 2.27 |
| molecular transducer activity | GO:0060089 | 2.32 |
| receptor activity | GO:0004872 | 2.32 |
| signal transducer activity | GO:0004871 | 2.28 |
| interleukin-6 receptor activity | GO:0004915 | 9.05 |
| growth factor binding | GO:0019838 | 4.89 |
| identical protein binding | GO:0042802 | 2.63 |
| cytokine receptor activity | GO:0004896 | 5.24 |
| ciliary neurotrophic factor binding | GO:0070119 | 9.74 |
| interleukin-6 receptor binding | GO:0005138 | 7.79 |
| receptor binding | GO:0005102 | 2.43 |
| growth factor receptor binding | GO:0070851 | 4.87 |
| interleukin-6 binding | GO:0019981 | 9.05 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| ciliary neurotrophic factor receptor activity | GO:0004897 | 8.35 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| binding | GO:0005488 | 0.18 |