| Disease ID | Disease name | Source of annotation with ITPR3 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 222100 | DIABETES MELLITUS, INSULIN-DEPENDENT | OMIM | link to OMIM | 5 | FOXP3, HNF1A, OAS1, ITPR3, PTPN22 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Platelet activation | hsa04611 | 5.66 |
| cGMP-PKG signaling pathway | hsa04022 | 5.32 |
| Calcium signaling pathway | hsa04020 | 5.22 |
| Long-term potentiation | hsa04720 | 6.64 |
| Retrograde endocannabinoid signaling | hsa04723 | 6.03 |
| Cholinergic synapse | hsa04725 | 5.88 |
| Glutamatergic synapse | hsa04724 | 5.84 |
| Serotonergic synapse | hsa04726 | 5.84 |
| Dopaminergic synapse | hsa04728 | 5.69 |
| Oxytocin signaling pathway | hsa04921 | 5.4 |
| Vascular smooth muscle contraction | hsa04270 | 5.74 |
| Gap junction | hsa04540 | 6.24 |
| Proteoglycans in cancer | hsa05205 | 5.02 |
| Oocyte meiosis | hsa04114 | 5.91 |
| GnRH signaling pathway | hsa04912 | 6.18 |
| Phosphatidylinositol signaling system | hsa04070 | 6.38 |
| Insulin secretion | hsa04911 | 6.18 |
| Inflammatory mediator regulation of TRP channels | hsa04750 | 6.07 |
| Estrogen signaling pathway | hsa04915 | 6.11 |
| Thyroid hormone synthesis | hsa04918 | 6.56 |
| Circadian entrainment | hsa04713 | 6.11 |
| Long-term depression | hsa04730 | 6.74 |
| Salivary secretion | hsa04970 | 6.23 |
| Gastric acid secretion | hsa04971 | 6.48 |
| Pancreatic secretion | hsa04972 | 6.07 |
| Alzheimer's disease | hsa05010 | 5.34 |
| Taste transduction | hsa04742 | 6.99 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 7.37 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 7.85 |
| DAG and IP3 signaling | R-HSA-1489509 | 7.98 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 7.52 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 5.47 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 7.46 |
| Immune System | R-HSA-168256 | 2.37 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 4.62 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 7.89 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Downstream signal transduction | R-HSA-186763 | 4.65 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 4.71 |
| Signalling by NGF | R-HSA-166520 | 4.23 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 7.43 |
| Signaling by VEGF | R-HSA-194138 | 4.66 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| Platelet calcium homeostasis | R-HSA-418360 | 8.73 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 8.34 |
| Ca2+ pathway | R-HSA-4086398 | 7.1 |
| Platelet homeostasis | R-HSA-418346 | 6.68 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 9.81 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 4.71 |
| Signaling by FGFR4 | R-HSA-5654743 | 4.69 |
| Signaling by FGFR3 | R-HSA-5654741 | 4.69 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.06 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 4.7 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 5.07 |
| Signaling by FGFR | R-HSA-190236 | 4.67 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 4.03 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| beta-catenin independent WNT signaling | R-HSA-3858494 | 5.83 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Integration of energy metabolism | R-HSA-163685 | 6.24 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 5.45 |
| Signaling by ERBB2 | R-HSA-1227986 | 4.66 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 9.52 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 6.38 |
| DAP12 signaling | R-HSA-2424491 | 4.64 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 4.71 |
| Signaling by EGFR | R-HSA-177929 | 4.59 |
| NGF signalling via TRKA from the plasma membrane | R-HSA-187037 | 4.51 |
| PLC-gamma1 signalling | R-HSA-167021 | 7.89 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 5.6 |
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| Regulation of insulin secretion | R-HSA-422356 | 6.66 |
| PLC beta mediated events | R-HSA-112043 | 7.52 |
| G-protein mediated events | R-HSA-112040 | 7.49 |
| Signaling by FGFR2 | R-HSA-5654738 | 4.68 |
| Signaling by FGFR1 | R-HSA-5654736 | 4.69 |
| Opioid Signalling | R-HSA-111885 | 6.64 |
| G alpha (q) signalling events | R-HSA-416476 | 5.42 |
| DAP12 interactions | R-HSA-2172127 | 4.56 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 4.71 |
| Signaling by PDGF | R-HSA-186797 | 4.53 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 5.07 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 7.59 |
| GO term | GO ID | GO IC |
|---|---|---|
| cation channel activity | GO:0005261 | 4.04 |
| calcium channel activity | GO:0005262 | 5.03 |
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | GO:0005220 | 8.64 |
| molecular transducer activity | GO:0060089 | 2.32 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| signaling receptor activity | GO:0038023 | 2.49 |
| divalent inorganic cation transmembrane transporter activity | GO:0072509 | 4.62 |
| cation binding | GO:0043169 | 1.4 |
| inositol hexakisphosphate binding | GO:0000822 | 9.05 |
| calcium-release channel activity | GO:0015278 | 6.97 |
| phospholipid binding | GO:0005543 | 3.91 |
| ligand-gated ion channel activity | GO:0015276 | 4.8 |
| ion binding | GO:0043167 | 1.36 |
| transmembrane transporter activity | GO:0022857 | 2.82 |
| calcium ion binding | GO:0005509 | 3.17 |
| passive transmembrane transporter activity | GO:0022803 | 3.6 |
| metal ion transmembrane transporter activity | GO:0046873 | 3.71 |
| metal ion binding | GO:0046872 | 1.41 |
| cation transmembrane transporter activity | GO:0008324 | 3.32 |
| calcium ion transmembrane transporter activity | GO:0015085 | 4.89 |
| transporter activity | GO:0005215 | 2.57 |
| ion channel activity | GO:0005216 | 3.71 |
| intracellular ligand-gated ion channel activity | GO:0005217 | 6.41 |
| lipid binding | GO:0008289 | 3.26 |
| small molecule binding | GO:0036094 | 1.89 |
| inositol 1,3,4,5 tetrakisphosphate binding | GO:0043533 | 8.35 |
| substrate-specific transmembrane transporter activity | GO:0022891 | 2.9 |
| inorganic cation transmembrane transporter activity | GO:0022890 | 3.49 |
| substrate-specific transporter activity | GO:0022892 | 2.72 |
| alcohol binding | GO:0043178 | 5.53 |
| phosphatidylinositol binding | GO:0035091 | 4.47 |
| inositol 1,4,5 trisphosphate binding | GO:0070679 | 7.54 |
| ion transmembrane transporter activity | GO:0015075 | 3.04 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| channel activity | GO:0015267 | 3.6 |
| gated channel activity | GO:0022836 | 3.96 |
| protein binding | GO:0005515 | 0.46 |
| ligand-gated channel activity | GO:0022834 | 4.8 |
| ligand-gated calcium channel activity | GO:0099604 | 6.97 |
| substrate-specific channel activity | GO:0022838 | 3.67 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| receptor activity | GO:0004872 | 2.32 |