Gene table of LCK : LCK proto-oncogene, Src family tyrosine kinase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with LCK	OMIM link	Number of associated genes	genes
615758	IMMUNODEFICIENCY 22	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	LCK

Download the gene annotation in CSV format

Annotation of the gene LCK

Associated genes in ENSEMBL

ENSG00000182866

Associated proteins - SwissProt Accession ID

P06239

Associated PDB IDs

Cytogenetic Band

1p35.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Natural killer cell mediated cytotoxicity	hsa04650	5.53
T cell receptor signaling pathway	hsa04660	6.01
Osteoclast differentiation	hsa04380	5.64
Primary immunodeficiency	hsa05340	7.52
NF-kappa B signaling pathway	hsa04064	6.21
HTLV-I infection	hsa05166	4.59

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Generation of second messenger molecules	R-HSA-202433	7.34
PD-1 signaling	R-HSA-389948	7.62
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	7.81
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59
PI3K/AKT activation	R-HSA-198203	6.32
Signaling by Interleukins	R-HSA-449147	4.71
GPVI-mediated activation cascade	R-HSA-114604	7.18
Immune System	R-HSA-168256	2.37
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Cell surface interactions at the vascular wall	R-HSA-202733	6.32
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Platelet activation, signaling and aggregation	R-HSA-76002	5.15
Downstream signal transduction	R-HSA-186763	4.65
GAB1 signalosome	R-HSA-180292	6.31
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	8.18
Signaling by ERBB4	R-HSA-1236394	4.7
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.59
Adaptive Immune System	R-HSA-1280218	3.19
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
Host Interactions of HIV factors	R-HSA-162909	5.99
Nef Mediated CD4 Down-regulation	R-HSA-167590	9.81
PIP3 activates AKT signaling	R-HSA-1257604	6.37
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.73
CTLA4 inhibitory signaling	R-HSA-389513	8.52
HIV Infection	R-HSA-162906	5.22
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
CD28 co-stimulation	R-HSA-389356	7.98
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
CD28 dependent Vav1 pathway	R-HSA-389359	9.4
Costimulation by the CD28 family	R-HSA-388841	6.56
Signaling by FGFR4	R-HSA-5654743	4.69
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Signaling by FGFR3	R-HSA-5654741	4.69
Infectious disease	R-HSA-5663205	4.47
Regulation of KIT signaling	R-HSA-1433559	8.98
Downstream TCR signaling	R-HSA-202424	7.01
Signaling by FGFR	R-HSA-190236	4.67
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Interleukin-2 signaling	R-HSA-451927	5.05
PECAM1 interactions	R-HSA-210990	9.4
Innate Immune System	R-HSA-168249	3.17
Signaling by SCF-KIT	R-HSA-1433557	4.73
Signaling by ERBB2	R-HSA-1227986	4.66
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
DAP12 signaling	R-HSA-2424491	4.64
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
Signaling by EGFR	R-HSA-177929	4.59
Nef and signal transduction	R-HSA-164944	9.98
Disease	R-HSA-1643685	3.33
Signalling by NGF	R-HSA-166520	4.23
Signaling by FGFR2	R-HSA-5654738	4.68
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
TCR signaling	R-HSA-202403	6.64
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
DAP12 interactions	R-HSA-2172127	4.56
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by PDGF	R-HSA-186797	4.53
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
protein C-terminus binding	GO:0008022	4.5
phosphatase activity	GO:0016791	4.11
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
phosphoric ester hydrolase activity	GO:0042578	3.82
small molecule binding	GO:0036094	1.89
binding	GO:0005488	0.18
phosphatidylinositol 3-kinase activity	GO:0035004	5.49
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	5.61
phosphatidylinositol 3-kinase binding	GO:0043548	6.41
CD4 receptor binding	GO:0042609	8.13
nucleoside phosphate binding	GO:1901265	1.96
nucleotide binding	GO:0000166	1.96
phosphatidylinositol bisphosphate kinase activity	GO:0052813	5.56
transferase activity	GO:0016740	1.95
non-membrane spanning protein tyrosine kinase activity	GO:0004715	5.91
protein tyrosine kinase activity	GO:0004713	4.54
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
ATP binding	GO:0005524	2.43
hydrolase activity	GO:0016787	1.9
SH2 domain binding	GO:0042169	6.34
ATPase binding	GO:0051117	5.41
kinase activity	GO:0016301	2.93
hydrolase activity, acting on ester bonds	GO:0016788	3.1
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
protein domain specific binding	GO:0019904	3.32
glycoprotein binding	GO:0001948	5.11
CD8 receptor binding	GO:0042610	9.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
catalytic activity	GO:0003824	1.05
protein serine/threonine phosphatase activity	GO:0004722	5.58
phosphoprotein phosphatase activity	GO:0004721	4.55
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
organic cyclic compound binding	GO:0097159	1.05
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19