| Disease ID | Disease name | Source of annotation with MAPT | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS168600 | PARKINSON DISEASE | OMIM | link to OMIM | 30 | ATP13A2, FGF20, VPS13C, DNAJC13, ATXN2, PINK1, CHCHD2, ADH1C, UCHL1, GIGYF2, SYNJ1, PODXL, HTRA2, LRRK2, TBP, PARK2, ATXN8OS, SNCAIP, GBA, SNCA, NR4A2, PLA2G6, GLUD2, PARK7, ATXN3, MAPT, DNAJC6, EIF4G1, FBXO7, VPS35 |
| 600274 | FRONTOTEMPORAL DEMENTIA | ClinVar, OMIM, HUMSAVAR | link to OMIM | 3 | GRN, MAPT, PSEN1 |
| 172700 | PICK DISEASE OF BRAIN | ClinVar, OMIM, HUMSAVAR | link to OMIM | 2 | MAPT, PSEN1 |
| 601104 | SUPRANUCLEAR PALSY, PROGRESSIVE, 1 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | MAPT |
| 260540 | PARKINSON-DEMENTIA SYNDROME | OMIM | link to OMIM | 1 | MAPT |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Alzheimer's disease | hsa05010 | 5.34 |
| MAPK signaling pathway | hsa04010 | 4.63 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 7.73 |
| Apoptotic execution phase | R-HSA-75153 | 7.28 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| Apoptosis | R-HSA-109581 | 5.68 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 9.4 |
| GO term | GO ID | GO IC |
|---|---|---|
| protein phosphatase 2A binding | GO:0051721 | 6.41 |
| lipoprotein particle binding | GO:0071813 | 6.56 |
| structural constituent of cytoskeleton | GO:0005200 | 5.12 |
| protein-lipid complex binding | GO:0071814 | 6.56 |
| cytoskeletal protein binding | GO:0008092 | 3.02 |
| microtubule binding | GO:0008017 | 4.42 |
| SH3 domain binding | GO:0017124 | 4.98 |
| enzyme binding | GO:0019899 | 2.27 |
| structural molecule activity | GO:0005198 | 3.1 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| protein phosphatase binding | GO:0019903 | 4.93 |
| phosphatase binding | GO:0019902 | 4.63 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| protein complex binding | GO:0032403 | 3.09 |
| tubulin binding | GO:0015631 | 4.1 |
| apolipoprotein binding | GO:0034185 | 6.97 |
| protein domain specific binding | GO:0019904 | 3.32 |