| Disease ID | Disease name | Source of annotation with MUTYH | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613659 | GASTRIC CANCER | OMIM, HUMSAVAR | link to OMIM | 9 | KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS |
| PS175100 | FAMAILIAL ADENOMATOUS POLYPOSIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 3 | APC, MUTYH, NTHL1 |
| 132600 | PILOMATRIXOMA | OMIM | link to OMIM | 2 | CTNNB1, MUTYH |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Base excision repair | hsa03410 | 7.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 9.81 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 11.4 |
| Cleavage of the damaged purine | R-HSA-110331 | 11.4 |
| Depurination | R-HSA-73927 | 11.4 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 7.85 |
| DNA Repair | R-HSA-73894 | 5.8 |
| Base Excision Repair | R-HSA-73884 | 7.85 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 9.66 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity, hydrolyzing N-glycosyl compounds | GO:0016799 | 6.6 |
| hydrolase activity, acting on glycosyl bonds | GO:0016798 | 4.91 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| cation binding | GO:0043169 | 1.4 |
| metal cluster binding | GO:0051540 | 5.55 |
| ion binding | GO:0043167 | 1.36 |
| MutSbeta complex binding | GO:0032408 | 9.74 |
| protein complex binding | GO:0032403 | 3.09 |
| metal ion binding | GO:0046872 | 1.41 |
| MutSalpha complex binding | GO:0032407 | 8.13 |
| MutLbeta complex binding | GO:0032406 | 9.74 |
| MutLalpha complex binding | GO:0032405 | 7.95 |
| mismatch repair complex binding | GO:0032404 | 7.66 |
| hydrolase activity | GO:0016787 | 1.9 |
| DNA N-glycosylase activity | GO:0019104 | 7.03 |
| catalytic activity | GO:0003824 | 1.05 |
| 4 iron, 4 sulfur cluster binding | GO:0051539 | 6.0 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| iron-sulfur cluster binding | GO:0051536 | 5.55 |
| protein binding | GO:0005515 | 0.46 |