Gene table of NOD2 : nucleotide binding oligomerization domain containing 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with NOD2	OMIM link	Number of associated genes	genes
PS266600	INFLAMMATORY BOWEL DISEASE	OMIM	link to OMIM	10	ATG16L1, IL10RB, IRGM, IL10RA, NOD2, IRF5, IL23R, ABCB1, SLC22A5, IL6
609464	SARCOIDOSIS, EARLY-ONSET	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	NOD2
186580	BLAU SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	NOD2
607507	PSORIATIC ARTHRITIS, SUSCEPTIBILITY TO	OMIM	link to OMIM	2	NOD2, LTA

Download the gene annotation in CSV format

Annotation of the gene NOD2

Associated genes in ENSEMBL

ENSG00000167207

Associated proteins - SwissProt Accession ID

Q9HC29

Associated PDB IDs

Cytogenetic Band

16q12.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
TNF signaling pathway	hsa04668	5.96
Shigellosis	hsa05131	6.74
Inflammatory bowel disease (IBD)	hsa05321	6.43
NOD-like receptor signaling pathway	hsa04621	6.88
Tuberculosis	hsa05152	5.17

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
TRIF-mediated TLR3/TLR4 signaling	R-HSA-937061	6.47
Signaling by Interleukins	R-HSA-449147	4.71
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51
Immune System	R-HSA-168256	2.37
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.73
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.73
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.47
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.31
Toll-Like Receptors Cascades	R-HSA-168898	5.91
MyD88-independent TLR3/TLR4 cascade	R-HSA-166166	6.47
Interleukin-1 signaling	R-HSA-446652	7.52
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.59
NOD1/2 Signaling Pathway	R-HSA-168638	7.85
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.68
Innate Immune System	R-HSA-168249	3.17
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	R-HSA-445989	8.08
MAP kinase activation in TLR cascade	R-HSA-450294	7.28
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.72
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.73
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.68
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56
Activated TLR4 signalling	R-HSA-166054	6.27
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	8.66
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.62

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
heat shock protein binding	GO:0031072	5.24
enzyme binding	GO:0019899	2.27
binding	GO:0005488	0.18
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
peptide binding	GO:0042277	4.22
Hsp70 protein binding	GO:0030544	6.37
CARD domain binding	GO:0050700	7.66
nucleotide binding	GO:0000166	1.96
actin binding	GO:0003779	3.74
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
Hsp90 protein binding	GO:0051879	6.37
ATP binding	GO:0005524	2.43
muramyl dipeptide binding	GO:0032500	9.74
amide binding	GO:0033218	4.14
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
protein domain specific binding	GO:0019904	3.32
small molecule binding	GO:0036094	1.89
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
cytoskeletal protein binding	GO:0008092	3.02
peptidoglycan binding	GO:0042834	7.25
glycosaminoglycan binding	GO:0005539	4.42
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19