Gene table of NOS3 : nitric oxide synthase 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with NOS3	OMIM link	Number of associated genes	genes
104300	ALZHEIMER DISEASE	OMIM	link to OMIM	13	HFE, PSEN2, ACE, APBB2, APP, A2M, PAXIP1, NOS3, MPO, PLAU, BLMH, PSEN1, SORL1
145500	HYPERTENSION, ESSENTIAL	OMIM	link to OMIM	13	RGS5, PTGIS, ADD1, NOS3, UMOD, AGT, ECE1, CYP3A5, ATP1B1, NOS2, GNB3, AGTR1, SELE
601367	STROKE, ISCHEMIC	OMIM	link to OMIM	5	PRKCH, NOS3, ALOX5AP, F5, F2
PS189800	PREECLAMPSIA/ECLAMPSIA	OMIM	link to OMIM	5	EPHX1, STOX1, AGT, NOS3, CORIN

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Annotation of the gene NOS3

Associated genes in ENSEMBL

ENSG00000164867

Associated proteins - SwissProt Accession ID

P29474

Associated PDB IDs

Cytogenetic Band

7q36.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Platelet activation	hsa04611	5.66
VEGF signaling pathway	hsa04370	6.77
Arginine and proline metabolism	hsa00330	6.84
cGMP-PKG signaling pathway	hsa04022	5.32
Metabolic pathways	hsa01100	2.49
Estrogen signaling pathway	hsa04915	6.11
HIF-1 signaling pathway	hsa04066	5.9
Calcium signaling pathway	hsa04020	5.22
Oxytocin signaling pathway	hsa04921	5.4
PI3K-Akt signaling pathway	hsa04151	4.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
eNOS activation	R-HSA-203615	9.98
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
NOSTRIN mediated eNOS trafficking	R-HSA-203641	10.66
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.34
Signal Transduction	R-HSA-162582	1.78
Signaling by VEGF	R-HSA-194138	4.66
eNOS activation and regulation	R-HSA-203765	8.81
Metabolism of nitric oxide	R-HSA-202131	8.81
Infectious disease	R-HSA-5663205	4.47
Metabolism	R-HSA-1430728	2.34
Latent infection of Homo sapiens with Mycobacterium tuberculosis	R-HSA-1222352	7.89
Platelet homeostasis	R-HSA-418346	6.68
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.66
Phagosomal maturation (early endosomal stage)	R-HSA-1222556	7.89
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.28
Hemostasis	R-HSA-109582	3.98
Disease	R-HSA-1643685	3.33
NOSIP mediated eNOS trafficking	R-HSA-203754	11.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
monooxygenase activity	GO:0004497	5.1
binding	GO:0005488	0.18
nucleotide binding	GO:0000166	1.96
amino acid binding	GO:0016597	5.71
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
oxidoreductase activity	GO:0016491	3.12
anion binding	GO:0043168	4.17
coenzyme binding	GO:0050662	4.53
NADP binding	GO:0050661	5.93
flavin adenine dinucleotide binding	GO:0050660	5.41
transition metal ion binding	GO:0046914	2.48
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO:0016709	6.07
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	4.65
ion binding	GO:0043167	1.36
actin binding	GO:0003779	3.74
FMN binding	GO:0010181	7.03
cadmium ion binding	GO:0046870	8.13
iron ion binding	GO:0005506	4.65
metal ion binding	GO:0046872	1.41
arginine binding	GO:0034618	7.79
nitric-oxide synthase activity	GO:0004517	8.64
heme binding	GO:0020037	4.86
cation binding	GO:0043169	1.4
tetrahydrobiopterin binding	GO:0034617	8.35
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cofactor binding	GO:0048037	4.16
actin monomer binding	GO:0003785	6.48
tetrapyrrole binding	GO:0046906	4.8
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
cytoskeletal protein binding	GO:0008092	3.02
carboxylic acid binding	GO:0031406	4.64
scaffold protein binding	GO:0097110	5.93
calmodulin binding	GO:0005516	4.55
protein binding	GO:0005515	0.46
ribonucleotide binding	GO:0032553	2.19