Gene table of PARN : poly(A)-specific ribonuclease

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PARN	OMIM link	Number of associated genes	genes
PS614742	PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED	ClinVar, OMIM, HUMSAVAR	link to OMIM	4	TERT, PARN, RTEL1, TERC
PS127550	DYSKERATOSIS CONGENITA	ClinVar, OMIM, HUMSAVAR	link to OMIM	10	NOP10, WRAP53, TERT, ACD, TINF2, PARN, RTEL1, NHP2, DKC1, TERC

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
RNA degradation	hsa03018	6.48

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
PERK regulates gene expression	R-HSA-381042	8.18
Unfolded Protein Response (UPR)	R-HSA-381119	6.56
Gene Expression	R-HSA-74160	2.72
ATF4 activates genes	R-HSA-380994	8.34
Metabolism of proteins	R-HSA-392499	3.41
Deadenylation of mRNA	R-HSA-429947	8.46
KSRP destabilizes mRNA	R-HSA-450604	8.89
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.56
Deadenylation-dependent mRNA decay	R-HSA-429914	7.37

Associated GO terms for Molecular function

GO term	GO ID	GO IC
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	GO:0016796	5.89
enzyme binding	GO:0019899	2.27
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
cation binding	GO:0043169	1.4
3'-5' exonuclease activity	GO:0008408	5.83
exonuclease activity	GO:0004527	5.33
ribonuclease activity	GO:0004540	5.04
ion binding	GO:0043167	1.36
mRNA 3'-UTR binding	GO:0003730	5.85
metal ion binding	GO:0046872	1.41
hydrolase activity	GO:0016787	1.9
poly(A) RNA binding	GO:0044822	2.69
hydrolase activity, acting on ester bonds	GO:0016788	3.1
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
exoribonuclease activity, producing 5'-phosphomonoesters	GO:0016896	6.37
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
nuclease activity	GO:0004518	4.33
organic cyclic compound binding	GO:0097159	1.05
poly(A)-specific ribonuclease activity	GO:0004535	7.25
exoribonuclease activity	GO:0004532	6.21
3'-5'-exoribonuclease activity	GO:0000175	6.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
mRNA binding	GO:0003729	4.68