Gene table of PIK3R5 : phosphoinositide-3-kinase regulatory subunit 5

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PIK3R5	OMIM link	Number of associated genes	genes
615217	ATAXIA-OCULOMOTOR APRAXIA 3	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	PIK3R5

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Annotation of the gene PIK3R5

Associated genes in ENSEMBL

ENSG00000141506

Associated proteins - SwissProt Accession ID

Q8WYR1

Associated PDB IDs

Cytogenetic Band

17p13.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Platelet activation	hsa04611	5.66
Fc gamma R-mediated phagocytosis	hsa04666	6.21
Small cell lung cancer	hsa05222	6.17
cGMP-PKG signaling pathway	hsa04022	5.32
Natural killer cell mediated cytotoxicity	hsa04650	5.53
Colorectal cancer	hsa05210	6.52
Renal cell carcinoma	hsa05211	6.6
Jak-STAT signaling pathway	hsa04630	5.44
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
cAMP signaling pathway	hsa04024	5.05
Prostate cancer	hsa05215	6.11
Leukocyte transendothelial migration	hsa04670	5.74
Cholinergic synapse	hsa04725	5.88
Choline metabolism in cancer	hsa05231	6.09
FoxO signaling pathway	hsa04068	5.63
Osteoclast differentiation	hsa04380	5.64
HIF-1 signaling pathway	hsa04066	5.9
Chemokine signaling pathway	hsa04062	5.19
Oxytocin signaling pathway	hsa04921	5.4
Aldosterone-regulated sodium reabsorption	hsa04960	7.41
VEGF signaling pathway	hsa04370	6.77
Focal adhesion	hsa04510	4.92
Endometrial cancer	hsa05213	6.81
Type II diabetes mellitus	hsa04930	7.12
Progesterone-mediated oocyte maturation	hsa04914	6.18
Chagas disease (American trypanosomiasis)	hsa05142	5.99
Pancreatic cancer	hsa05212	6.56
Amoebiasis	hsa05146	5.82
Epstein-Barr virus infection	hsa05169	4.97
Toxoplasmosis	hsa05145	5.71
Influenza A	hsa05164	5.21
Apoptosis	hsa04210	6.23
HTLV-I infection	hsa05166	4.59
PI3K-Akt signaling pathway	hsa04151	4.21
Hepatitis C	hsa05160	5.68
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
B cell receptor signaling pathway	hsa04662	6.52
Chronic myeloid leukemia	hsa05220	6.48
Bacterial invasion of epithelial cells	hsa05100	6.34
Proteoglycans in cancer	hsa05205	5.02
Toll-like receptor signaling pathway	hsa04620	6.0
Pathways in cancer	hsa05200	3.98
Viral carcinogenesis	hsa05203	5.08
T cell receptor signaling pathway	hsa04660	6.01
Phosphatidylinositol signaling system	hsa04070	6.38
Rap1 signaling pathway	hsa04015	4.97
Ras signaling pathway	hsa04014	4.9
Inflammatory mediator regulation of TRP channels	hsa04750	6.07
Prolactin signaling pathway	hsa04917	6.6
Acute myeloid leukemia	hsa05221	6.74
Estrogen signaling pathway	hsa04915	6.11
TNF signaling pathway	hsa04668	5.96
Thyroid hormone signaling pathway	hsa04919	5.82
AMPK signaling pathway	hsa04152	5.8
mTOR signaling pathway	hsa04150	6.72
Regulation of actin cytoskeleton	hsa04810	4.9
Carbohydrate digestion and absorption	hsa04973	7.28
Non-small cell lung cancer	hsa05223	6.88
Insulin signaling pathway	hsa04910	5.55
Neurotrophin signaling pathway	hsa04722	5.78
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51
Central carbon metabolism in cancer	hsa05230	6.7
Glioma	hsa05214	6.66
Fc epsilon RI signaling pathway	hsa04664	6.6
Adrenergic signaling in cardiomyocytes	hsa04261	5.44
ErbB signaling pathway	hsa04012	6.15

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.94
GPVI-mediated activation cascade	R-HSA-114604	7.18
Signaling by GPCR	R-HSA-372790	2.68
GPCR downstream signaling	R-HSA-388396	3.07
Platelet activation, signaling and aggregation	R-HSA-76002	5.15
Phospholipid metabolism	R-HSA-1483257	5.83
G-protein beta:gamma signalling	R-HSA-397795	7.31
PI Metabolism	R-HSA-1483255	7.31
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4
Metabolism	R-HSA-1430728	2.34
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	5.61
1-phosphatidylinositol-3-kinase regulator activity	GO:0046935	7.95
G-protein beta/gamma-subunit complex binding	GO:0031683	6.65
kinase regulator activity	GO:0019207	4.5
protein binding	GO:0005515	0.46
catalytic activity	GO:0003824	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
enzyme regulator activity	GO:0030234	2.85
kinase activity	GO:0016301	2.93
phosphatidylinositol bisphosphate kinase activity	GO:0052813	5.56
transferase activity	GO:0016740	1.95
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
phosphatidylinositol 3-kinase activity	GO:0035004	5.49
protein complex binding	GO:0032403	3.09
molecular function regulator	GO:0098772	2.51
phosphatidylinositol 3-kinase regulator activity	GO:0035014	7.79