Gene table of PPARG : peroxisome proliferator activated receptor gamma

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PPARG	OMIM link	Number of associated genes	genes
PS137800	GLIOMA	ClinVar	link to OMIM	8	PTEN, PPARG, ERBB2, POT1, BRCA2, IDH2, IDH1, TP53
125853	DIABETES MELLITUS, NONINSULIN-DEPENDENT	OMIM	link to OMIM	33	SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11
PS151660	LIPODYSTROPHY, FAMILIAL PARTIAL	ClinVar, OMIM, HUMSAVAR	link to OMIM	6	PPARG, LIPE, PLIN1, CIDEC, LMNA, PPP1R3A
601665	OBESITY	OMIM, HUMSAVAR	link to OMIM	15	AGRP, PPARGC1B, PPARG, MC4R, ADRB3, CARTPT, UCP3, SIM1, POMC, ENPP1, ADRB2, SDC3, NR0B2, UCP1, GHRL
609338	CAROTID INTIMAL MEDIAL THICKNESS 1	OMIM	link to OMIM	1	PPARG

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Annotation of the gene PPARG

Associated genes in ENSEMBL

ENSG00000132170

Associated proteins - SwissProt Accession ID

P37231

Associated PDB IDs

Cytogenetic Band

3p25.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Thyroid cancer	hsa05216	7.48
PPAR signaling pathway	hsa03320	6.56
Pathways in cancer	hsa05200	3.98
Transcriptional misregulation in cancer	hsa05202	5.21
Osteoclast differentiation	hsa04380	5.64
Huntington's disease	hsa05016	5.17
AMPK signaling pathway	hsa04152	5.8

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
PPARA activates gene expression	R-HSA-1989781	6.18
Nuclear Receptor transcription pathway	R-HSA-383280	7.31
Generic Transcription Pathway	R-HSA-212436	3.86
Gene Expression	R-HSA-74160	2.72
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	R-HSA-400206	6.14
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7
Metabolism	R-HSA-1430728	2.34
Fatty acid, triacylglycerol, and ketone body metabolism	R-HSA-535734	5.44
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79
Developmental Biology	R-HSA-1266738	3.48

Associated GO terms for Molecular function

GO term	GO ID	GO IC
receptor activity	GO:0004872	2.32
signaling receptor activity	GO:0038023	2.49
nucleic acid binding	GO:0003676	1.44
activating transcription factor binding	GO:0033613	5.68
transcription coactivator activity	GO:0003713	4.04
enzyme binding	GO:0019899	2.27
drug binding	GO:0008144	5.03
molecular transducer activity	GO:0060089	2.32
transcription factor activity, direct ligand regulated sequence-specific DNA binding	GO:0098531	5.87
steroid hormone receptor binding	GO:0035258	5.32
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	GO:0004879	5.87
anion binding	GO:0043168	4.17
sequence-specific DNA binding	GO:0043565	2.79
G-protein coupled receptor activity	GO:0004930	2.95
sequence-specific double-stranded DNA binding	GO:1990837	3.2
transition metal ion binding	GO:0046914	2.48
transcription regulatory region DNA binding	GO:0044212	3.03
zinc ion binding	GO:0008270	2.66
transcription cofactor activity	GO:0003712	3.44
ion binding	GO:0043167	1.36
long-chain fatty acid binding	GO:0036041	7.44
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
fatty acid binding	GO:0005504	6.37
actinin binding	GO:0042805	6.3
double-stranded DNA binding	GO:0003690	3.09
metal ion binding	GO:0046872	1.41
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
alpha-actinin binding	GO:0051393	6.6
nucleic acid binding transcription factor activity	GO:0001071	2.65
estrogen receptor binding	GO:0030331	6.05
cation binding	GO:0043169	1.4
regulatory region nucleic acid binding	GO:0001067	3.03
transcription factor binding	GO:0008134	3.46
nuclear hormone receptor binding	GO:0035257	4.7
lipid binding	GO:0008289	3.26
ligand-dependent nuclear receptor transcription coactivator activity	GO:0030374	5.77
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
core promoter binding	GO:0001047	4.71
core promoter sequence-specific DNA binding	GO:0001046	5.12
hormone receptor binding	GO:0051427	4.57
monocarboxylic acid binding	GO:0033293	5.61
icosanoid binding	GO:0050542	7.95
icosatetraenoic acid binding	GO:0050543	7.95
arachidonic acid binding	GO:0050544	8.13
cytoskeletal protein binding	GO:0008092	3.02
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
carboxylic acid binding	GO:0031406	4.64
retinoid X receptor binding	GO:0046965	6.79
steroid hormone receptor activity	GO:0003707	5.66
transmembrane signaling receptor activity	GO:0004888	2.57
icosanoid receptor activity	GO:0004953	7.03
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
retinoic acid receptor binding	GO:0042974	5.83
prostanoid receptor activity	GO:0004954	7.44
receptor binding	GO:0005102	2.43
chromatin binding	GO:0003682	3.64
transmembrane receptor activity	GO:0099600	2.53
prostaglandin receptor activity	GO:0004955	7.54