Gene table of REST : RE1 silencing transcription factor

Gene-disease associations table

Disease ID	Disease name	Source of annotation with REST	OMIM link	Number of associated genes	genes
PS194070	WILMS TUMOR	ClinVar, OMIM	link to OMIM	6	WT1, REST, H19, GPC3, BRCA2, POU6F2

Download the gene annotation in CSV format

Annotation of the gene REST

Associated genes in ENSEMBL

ENSG00000084093

Associated proteins - SwissProt Accession ID

Q13127

Associated PDB IDs

2czy

Cytogenetic Band

4q12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Huntington's disease	hsa05016	5.17

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
HDACs deacetylate histones	R-HSA-3214815	7.08
Chromatin organization	R-HSA-4839726	5.19
Chromatin modifying enzymes	R-HSA-3247509	5.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
potassium channel activity	GO:0005267	4.94
cation channel activity	GO:0005261	4.04
cation binding	GO:0043169	1.4
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
substrate-specific channel activity	GO:0022838	3.67
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001078	5.08
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
histone deacetylase activity	GO:0004407	6.0
transcription factor binding	GO:0008134	3.46
outward rectifier potassium channel activity	GO:0015271	7.44
transmembrane transporter activity	GO:0022857	2.82
ion binding	GO:0043167	1.36
voltage-gated cation channel activity	GO:0022843	4.83
protein complex binding	GO:0032403	3.09
passive transmembrane transporter activity	GO:0022803	3.6
metal ion transmembrane transporter activity	GO:0046873	3.71
metal ion binding	GO:0046872	1.41
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
hydrolase activity	GO:0016787	1.9
deacetylase activity	GO:0019213	5.7
voltage-gated potassium channel activity	GO:0005249	5.24
inorganic cation transmembrane transporter activity	GO:0022890	3.49
transporter activity	GO:0005215	2.57
ion channel activity	GO:0005216	3.71
cation transmembrane transporter activity	GO:0008324	3.32
regulatory region nucleic acid binding	GO:0001067	3.03
catalytic activity	GO:0003824	1.05
core promoter binding	GO:0001047	4.71
core promoter sequence-specific DNA binding	GO:0001046	5.12
double-stranded DNA binding	GO:0003690	3.09
substrate-specific transmembrane transporter activity	GO:0022891	2.9
transcription regulatory region DNA binding	GO:0044212	3.03
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001227	4.61
substrate-specific transporter activity	GO:0022892	2.72
voltage-gated ion channel activity	GO:0005244	4.49
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO:0016810	4.76
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	GO:0016811	5.28
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
ion transmembrane transporter activity	GO:0015075	3.04
voltage-gated channel activity	GO:0022832	4.49
monovalent inorganic cation transmembrane transporter activity	GO:0015077	3.87
channel activity	GO:0015267	3.6
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
gated channel activity	GO:0022836	3.96
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
protein deacetylase activity	GO:0033558	5.95
chromatin binding	GO:0003682	3.64
potassium ion transmembrane transporter activity	GO:0015079	4.77
nucleic acid binding transcription factor activity	GO:0001071	2.65