Gene table of RUNX1 : runt related transcription factor 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with RUNX1	OMIM link	Number of associated genes	genes
601626	LEUKEMIA, ACUTE MYELOID	OMIM	link to OMIM	23	FLT3, RUNX1, WHSC1L1, KIT, MLF1, CHIC2, CEBPA, LPP, SH3GL1, PICALM, NPM1, CBFB, ETV6, SETBP1, MLLT10, TERT, NUP214, JAK2, GATA2, TGM6, DDX41, NSD1, KRAS
601399	PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	RUNX1

Download the gene annotation in CSV format

Annotation of the gene RUNX1

Associated genes in ENSEMBL

ENSG00000159216

Associated proteins - SwissProt Accession ID

Q01196

Associated PDB IDs

Cytogenetic Band

21q22.12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Chronic myeloid leukemia	hsa05220	6.48
Pathways in cancer	hsa05200	3.98
Acute myeloid leukemia	hsa05221	6.74
Transcriptional misregulation in cancer	hsa05202	5.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
SLC-mediated transmembrane transport	R-HSA-425407	4.95
Organic cation/anion/zwitterion transport	R-HSA-549132	9.18
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	R-HSA-425366	6.34
Transmembrane transport of small molecules	R-HSA-382551	3.79
Organic cation transport	R-HSA-549127	9.81

Associated GO terms for Molecular function

GO term	GO ID	GO IC
3',5'-cyclic-nucleotide phosphodiesterase activity	GO:0004114	6.52
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
cyclic-nucleotide phosphodiesterase activity	GO:0004112	6.48
phosphoric ester hydrolase activity	GO:0042578	3.82
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
ion binding	GO:0043167	1.36
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
phosphoric diester hydrolase activity	GO:0008081	5.23
transcription corepressor activity	GO:0003714	4.33
transcription cofactor activity	GO:0003712	3.44
nucleotide binding	GO:0000166	1.96
purine ribonucleoside triphosphate binding	GO:0035639	2.22
identical protein binding	GO:0042802	2.63
calcium ion binding	GO:0005509	3.17
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
purine nucleotide binding	GO:0017076	2.19
double-stranded DNA binding	GO:0003690	3.09
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
protein homodimerization activity	GO:0042803	3.16
hydrolase activity	GO:0016787	1.9
cation binding	GO:0043169	1.4
transcription factor binding	GO:0008134	3.46
ribonucleoside binding	GO:0032549	2.22
regulatory region nucleic acid binding	GO:0001067	3.03
purine nucleoside binding	GO:0001883	2.22
hydrolase activity, acting on ester bonds	GO:0016788	3.1
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
core promoter binding	GO:0001047	4.71
transcription regulatory region DNA binding	GO:0044212	3.03
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
adenyl nucleotide binding	GO:0030554	2.4
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
nucleic acid binding transcription factor activity	GO:0001071	2.65
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
carbohydrate derivative binding	GO:0097367	2.03
adenyl ribonucleotide binding	GO:0032559	2.41
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
protein heterodimerization activity	GO:0046982	3.64
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29